Adalimumab

[vonniesims]

Does anyone else find this does not last a fortninght between doses?I am on Amgevita and get really uncomfortable and tired on days11 ,12 and 13

Nurse has suggested increasing dose of Methotrexate from 15mg to 20 to try that, just wondered if anyone else experiences this and how they manage it

[Wobbies]

When this happened to me and my nephew the rheumy changed the biologic.

[vonniesims in reply to Wobbies]

Ooh. My rheumatologist is reluctant to change it as he's worried about running out of Biologics. I've only been on one other! I only get 7 decent days as it takes a couple of days to kick in too

Thankyou , I might push more for a change

[patsymay13 in reply to vonniesims]

think you could maybe ask to be put on weekly dose

[vonniesims in reply to patsymay13]

Thankyou, I will ask

[Brian1977]

I've been on it since beginning of June as well as 25mg weekly methotrexate and I don't feel any better plus the inflammation has returned to my colon too 🙈🙈🙈

[vonniesims in reply to Brian1977]

I think they will tell you to give it up to 12 weeks to kick in. Good luck

[Brian1977]

My rheumatology team are really good and on the ball. I've to go for an urgent colonoscopy to see how bad the inflammation is in my colon again but the amgevita should be helping the inflammation in my bowels too so who knows what will happen

[CagneysMum]

Hi.

I felt better only hours after injecting adalimumab for the first time but it took 3 months or so for that effect to last the whole two weeks. I’ve been on it almost 3 years and it works really well for me although I still have occasional days where I’m good for nothing exhausted … but no particular pattern to them.

[Joodee]

This happened to me when I’d been on humira for about 12 years. I kept mentioning it at appointments and eventually the consultant changed my biologic and told me that they’d seen quite a few people for whom humira gradually stopped being effective. I would push for a change in biologic. I’m on Olumiant now and feeling so much better.

[vonniesims in reply to Joodee]

Thankyou, I've only been on it 14 months. Think I will start a diary

[oldtimer2]

I discussed this very question at my rheumatology appointment last week. The consultant had been going to reduce my DMARD again (reduced last year) but in view of that decided not to. He said, if it worsens (i.e. symptoms start appearing earlier or are worse) another biological will need to be considered.

[Carolsos]

I came of humeria because it didn't last 2 weeks, I was in agony and they changed me onto benpalli biological instead, every week injection. Loads better. Ask for another biological instead. It's your body! Good luck.

[vonniesims in reply to Carolsos]

Thankyou

[Kitten15]

I've been on Adalimumab since January it only started working April time felt great then been having breakthrough pain a week before I'm due to inject again so thinking the drug has stopped working so maybe this is what your experiencing as well..... It's tough, isn't it!!!.i'm due to see rheum on Tuesday after getting called in after having another routine mri scan the start of june, so I got a letter in to see them early for results so I'm guessing something isn't quite right as my apmnt wasn't till November time. Really hope you see your rheumatologist soon to discuss your concerns as you don't want to keep plodding on if your in agony and risk more damage with inflammation. Good luck

[vonniesims in reply to Kitten15]

I've done better this last fortnight, but the air pressure is low at the moment so that helps.

[Kitten15]

Glad to hear it Vonniesims and yeah the low air pressure does seem to help . Take good care