WHY HAS CO-PROXAMOL BECOME SO EXPENSIVE? : MHRA have... - NRAS

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WHY HAS CO-PROXAMOL BECOME SO EXPENSIVE?

Whowillgiveastuff profile image

MHRA have continually protected the identity of the unscrupulous importers until the intervention by the ICO when they finally disclosed all the licenced importers in November 2022.

My first FOI request to MHRA asking MHRA to disclose the names of licensed UK importers of Co-proxamol was 19th August 2018. Following the intervention of ICO I finally received the requested information on 4th November 2022.

During the 12 month period March 2020 — February 2021 NHS CCG'S squandered  £2,261,377 on Co-proxamol for just 9,906 prescriptions! This equated to the average prescription costing the NHS £228.28!

This situation continued during the period June 2021 to May 2022 NHS CCG's continued to pay the more exorbitant price spending £2,127,269 on Co-proxamol for 7,413 Items! Average cost per item £286.96

TELEGRAPH ARTICLE:

Pharmaceutical scandal: 'You pay us £300. However, your invoice will say £600. So £300 stays with you.'

telegraph.co.uk/news/health...

For high street chemists across Britain, the annual Pharmacy Congress is one of the highlights in the business calendar.

By Holly Watt Claire Newell and Ben Bryant;

20 June 2013 • 9:20pm

Held earlier this year, at London’s ExCeL Centre, the event allows chemists to mingle with Drug Company executives, talking business during the day before the trays of white wine arrive in the evening and the socialising begins.

However, unlike similar sales events, some of the conversations taking place were not focused on cutting the best deal to keep costs down – but rather on how to inflate some prices that would ultimately land on the taxpayer.

Unknown to those present, among the delegates at this year’s congress were undercover reporters from The Daily Telegraph investigating the market in so-called “specials” drugs, after being informed by a whistle-blower of a number of serious allegations of malpractice.

Specials” are the thousands of prescription drugs that are largely not covered by national pricing rules.

The undercover reporters were claiming to represent a new chain of chemists and asked executives from pharmaceutical companies about a range of practices which appeared to amount to the NHS being ripped off.

Within minutes of the conversations beginning, it became apparent that the executives were prepared to enter into highly questionable arrangements which legal experts said last night should be investigated.

An executive from Pharmarama, a company based in Hertfordshire, was happy to describe how pharmacies could exploit the NHS system for funding specials with so-called “rebates” or discounts. “Explain the rebate again?” asked a reporter, in the middle of the crowds of delegates.

“Rebate is where we will charge you a certain amount,” said Dhruv Patel, the head of unlicensed pharmaceutical sales at Pharmarama.

“Ok, let’s say £600.00,” said the reporter.

“£600.00 you pay us £300.00 however, your invoice will say £600.00,” said Mr Patel. “So £300.00 stays with you.”

The £600.00 billed by Pharmarama would be refunded to the chemist in full by the NHS — with the drugs firm and the chemist effectively splitting the proceeds.

Mr Patel then explained how the company would provide credit notes and pointed out that the NHS only had the capacity to look at invoices rather than conduct any forensic analysis of a company’s income.

Mr Patel gave an example of how discussion of the payment would proceed between the chemist and NHS officials.

“Can you show me an invoice to show that you’ve actually paid £600.00? Of course I can. There you go.

“Er, that’s it,” explained Mr Patel.

He also boasted that the company knew where the “thresholds” were for different local NHS bodies without raising alarm bells.

Several pharmaceutical companies have the ability to supply the huge range of “specials” now being marketed, with chemists able to supply — and charge taxpayers — for more than 20,000 different products.

Quantum Pharmaceutical, which describes itself as the leading supplier of “specials” and was at the conference, offered a slightly different arrangement when undercover reporters met one of its managers in Newcastle.

Leo McDermott, its business development general manager, said: “We’ll charge you 150 per cent [of the cost of the drug]. Your 50 per cent stays in the Royal Bank of Quantum until you see fit to claim it back.” Mr McDermott also suggested that his company could supply generic drugs free of charge in return for the right to supply the chain of pharmacies with special drugs.

Reporting a conversation he said had taken place with a high street chemist, he said: “I said 'you’ve got an account with [generic drug manufacturer], why don’t I just buy two and a half grand’s worth of generics from them, we’ll get it delivered into Quantum and then delivered [to you]’. So we’re not, no one’s breaking the law. We’re not laundering money or anything,” said Mr McDermott.

Alternatively, he suggested simply invoicing Quantum at regular intervals, with around £10,000 a month being paid to the pharmacy chain for its business.

“Or you can write us an invoice for £10,000 … simple as that. And between two large companies that’s completely legal. Quantum has had the best lawyers in the world on this. It’s completely legal. And little Mr Patel on the high street [thought to be a reference to chemists] they like to duck and dive and get the money back in different ways but a large company like you guys, you, you invoice me once a quarter for £40,000. Dead easy, dead easy,” he said.

Zaheer Mushtaq, an executive from another drug company, Temag, which was represented at the conference, said in a meeting at his firm’s offices that his company would provide “almost like a duplicate invoice if you like — a double invoice, one with before discount and then after the discount so they can see the amount of discount that they’re getting.” Mr Mushtaq said that after the company supplied the two invoices it would be up to the pharmacy which one they claimed back from the NHS.

“You could call that slightly perhaps underhand, but you know if that’s generally what they want, all we’re doing is we’re just endorsing the price. And the discount will go back to the pharmacies, and it’s up to them …”

Another way of maximising payments from the NHS is a practice known as the “wholesale” system, which one executive described as the “magic triangle”.

Under this system, the pharmaceutical company sells the drug to a wholesaler, who then sells it on to the pharmacy at an inflated price. The pharmacy then invoices the NHS. Some representatives suggested that the undercover reporters may also want to set up a wholesaler — at arm’s length.

“If you have friends who you see who have a wholesaler dealer’s licence — and I do — then that might work to your advantage of how you would like to structure a deal,” said Mr McDermott, of Quantum. “First of all we need the relationship. We need to understand that. The problem is every time you bring a third party in, everybody needs to win. If you know what I mean.”

Mr McDermott explained that the wholesaler and the pharmacy needed to “appear to be different”.

“Well, one might be owned by his wife. One might be owned by …”

Tonight the companies named denied wrongdoing and two of them launched investigations.

Magdalena Kulbat, of Temag, said: “It would be totally unrepresentative to make any suggestion that we are involved in any sort of practice to unfairly charge the NHS … we are not involved in anything that seeks to be fictitious to make money from supplies to chemists.”

She said that it was “totally inaccurate” to suggest that the company supplies “duplicate invoices with different amounts”.

A spokesman for PIL [Pharmarama International Limited], said they were investigating the allegations made by The Telegraph. “Our initial inquiries suggest strongly that the issue at stake relates to inappropriate and overenthusiastic claims made at a sales meeting.”

The spokesman said their company “has never conspired with pharmacists” and they do “not offer a rebate scheme”.

However, they admitted that on a “small number of occasions, we have complied with a customer request to invoice at the full price and offer a negotiated discount by way of a credit note”, but when this happened, they reminded the pharmacists of their “obligation under the NHS Act to keep the NHS properly informed”.

A spokesman for Quantum Pharmaceutical said they were investigating the allegations and had suspended a member of staff.

“The alleged views of this individual do not represent the business practice of this company,” said the spokesman.

“Wholesalers are prevalent throughout the sector, but it is not our position or policy to advise whether customers should or should not operate a wholesale licence … the alleged views of this individual do not represent our business practices.”

They said that they did not give “monies in return for customer trading” and offered “lawful, competitive and transparent discounts”. The spokesman said they were “legally entitled to offer discounts” and it was common business practice.

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Whowillgiveastuff
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7 Replies
AgedCrone profile image
AgedCrone

I’m confused…is the point you are making that the NHS…is spending money needlessly, that it is known about & that nobody seems to be doing anything about it?

Or are you interested in Co-proxamol being available on prescription to anyone- not just named patients?

Whowillgiveastuff profile image
Whowillgiveastuff in reply to AgedCrone

Yes NHS is spending money needlessly, and has known about this situation since November 2015!

I've been in contact with Simon Stevens the previous CEO at england.ce@nhs.net, and have issued a ‘Service Complaint’ to NHS England england.contactus@nhs.net (For the attention of the complaints team) and just about every department in the NHS and DOHSC without any success!

I strongly feel that Co-proxamol should be available on prescription to everyone who needs it as it was far safer than any of the alternatives that MHRA have licensed since the ban!

AgedCrone profile image
AgedCrone in reply to Whowillgiveastuff

Well, as you probably know it was taken off licence because of the high number of suicides attributed to it…..so it is going to take a brave person to put their head above the parapet to fight to bring it back….especially as there are still quite a large number of legal prescriptions available to named patients……who managed to prove any substitutes were not as effective.

Whowillgiveastuff profile image
Whowillgiveastuff in reply to AgedCrone

I know I was a ‘Named Patient’ My Service Complaint to:

-----Original Message-----

From: Redactedxxx

To: enquiries@nhsconfed.org ; england.casework@nhs.net ; derek@midlandsandlancashirecsu.nhs.uk

CC: katherine.fletcher.mp@parliament.uk

Sent: Wed, 17 Nov 2021 7:40

Subject: Service Complaint Co-proxamol deprescribing

Service Complaint to:

FAO Graham Jackson NHSCC enquiries@nhsconfed.org

FAO Amanda Pritchard CEO NHS england.casework@nhs.net

FAO Derek Kitchen Managing Director derek@midlandsandlancashirecsu.nhs.uk

I have been trying to get answers regarding the Co-proxamol debacle since my prescription as a ‘Named Patient’ was cancelled during November 2015. My health and wellbeing has been ruined for no good reason!

Each of the three organisations have previously denied any responsibility for this dire situation, I maintain all three are responsible to some degree and I expect a full explanation why sixty thousand ‘Named Patients’ have been put at risk from uncontrolled pain, horrendous side effects, addiction, premature death, and the NHS having to pay ever increasing prices for Co-proxamol.

I have gained an enormous amount of information since 2005 which proves beyond any doubt the reasoning behind the ban was totally false. The only organisations to gain from this ban have been MHRA who have gained more than eight million pounds annually and the Pharmaceutical companies who have gained by selling the more dangerous and expensive opiates / opioids from the additional 298 ‘Marketing Authorisations’ issued by MHRA since the ban was announced during 2005 and 2015.

There are many direct equivalent formulations for Co-proxamol which have been available for import since 2017. The closest equivalent for Immediate Import to the UK would cost just £0.66 pence per Box (100 Tablets) plus shipping and import charges. The only difference between Co-proxamol and Parvon-N is an additional 25mg of paracetamol which is safe, negligible, and probably more beneficial for patients. Just like Co-proxamol it is an unlicensed drug and should have been made available for prescribing to ‘Named Patients’ at an extremely cost effective price!

Fourteen years after the ban had been introduced the NHS continued to spend £2,261,377 on the 9906 Co-proxamol Items prescribed last year. Average price per item £228.00.

Parvon-N and Co-proxamol are both unlicensed drugs, and it’s perfectly legal for GP’s to prescribe unlicensed medications if it’s in their patient’s best interest.

All 60,000 named patients had proved beyond any doubt they needed the drug and their GP’s agreed to continue prescribing until PrescQipp advised CCG’s to deprescribe during 2013, and 2015 followed by NHSCC announcing the outcome of their optimisation consultation during November 2017.

The outcome of the optimisation consultation for Co-proxamol has clearly achieved NO SAVINGS and added millions of pounds to the NHS budget for many years to come!

Parvon-N has been available for import since 2017 for just £0.66 pence per box (100 tablets) plus shipping and import costs. The total cost to supply the 60,000 ‘Named Patients’ with Parvon-N for twelve months and the 9.906 remaining prescriptions….. Continued

Suicide/Open reports had reduced from 296 in 2000 to just 204 in 2004 A 7% REDUCTIONS HAD BEEN ACHEIVED! Further reductions could have been guaranteed by simply changing the drug classification to ‘Schedule 3 controlled’. I feel sure if the classification had been changed Co-proxamol would have remained on the market today at a very competitive price for the NHS! (2000 - 2004) the chart below clearly shows a 7% reduction in Co-proxamol Suicides prior to the ban being announced! This fact contradicts MHRA's reasoning for the original ban!

Suicide Reductions Prior to the Ban being Announced!
Susiebee31 profile image
Susiebee31 in reply to Whowillgiveastuff

I found co- proxamol to be the best painkiller but got taken off it not that I wanted to. I’m no on fentanyl patches and tramadol prn. I’d be happy to go back on it instead of what I’m taking now!

Whowillgiveastuff profile image
Whowillgiveastuff in reply to Susiebee31

Hi Susie,

I’m trying to find out how much the NHS is overpaying for the inferior and more dangerous medications substituted for Co-proxamol when there has been a direct alternative to Co-proxamol (D Vic capsules) available for less than £2.00 per month at maximum safe dose (224 Capsules).

I would appreciate you letting me know the strength and monthly amount of Fentanyl patches and the average number of Tramadol you would take in a month.

I don’t want to alarm you in any way, however the facts in the following picture show the truth.

Problems with the Alternate Analgesia
Green230461 profile image
Green230461

This is absolutely dreadful! No wonder the NHS is on its last legs

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