Forgive me if someone else posted this already, but I read about a vaccine that was discovered accidentally that looks like it will cure r.a here is the link:. drugtargetreview.com/news/9...
New cure for rheumatoid arthritis not yet in clinical... - NRAS
New cure for rheumatoid arthritis not yet in clinical trials
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SpaghettiIsGood
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Wow that would be amazing!!!
Sounds good
Could be great for the next generation, as if it stops it developing that would be awesome. Not yet at pre-clinical stage tho’, so many many more years to go.
I kept looking for a clinical trial (not knowing it takes years).
They have to make sure the mice are ok first….and looks like they don’t yet have funding to get to next stage. This is how long it can take, and shows very few new drugs get to our bathroom cabinets
Time line diagram of drug debelopment
I was searching for this illustration, eventually gave up so thanks for posting this h.
Seems like it's in stage two?
The end of the article says they are looking for funding to do a pre-clinical trial, so not sure. May have done the in vitro (ie lab tests), and now want to move on to in-vivo
For anyone interested, you can access an abstract of the original paper through the link labelled PNAS towards the end of the article, but the full paper is unfortunately behind a paywall. Whilst it would be amazing if this eventually came to pass, having followed many drugs and treatments for other life-long conditions through the theoretical stages to clinical trials and seen them crash and burn, I would hesitate to describe it as a potential cure just yet. It’s a novel vaccine that’s shown effect in rats with man-made inflammatory disease, that’s been triggered by altering very specific elements of their biology. The problem with that is we still don’t truly understand the various disease mechanisms behind IA in humans, so it doesn’t necessarily equate that the effect will translate. Hopefully it will, but even if it does, it’s likely going to be a long process. Don’t get me wrong, I’m not being negative, just don’t want people to get their hopes up at such an early stage. It’s definitely one to watch with interest over the next few years, for sure.
SpaghettiIsGood• in reply to
My hopes are up anyway. This is my only hope for a cure. They seem so certain about this one. Have you seen in the past where it seemed so certain, only to see it crash and burn?
• in reply toSpaghettiIsGood
Hiya. Like I said, I’m not trying to be negative, but yes, I’ve seen many drugs that were considered highly promising fail for various reasons and never make it to production. Not for arthritis, but for a number of other conditions that my daughter and I have between us. The results of this are promising, but there is no certainty it’ll work even amongst the medics that wrote the paper, there can’t be, because it’s still in pretty much the earliest stage of development and treating a man-made disease in a rat is a very different thing to treating organic disease in a person, particularly when we don’t fully understand the mechanisms that cause the disease. Even if it was found to work in humans, the likelihood is we’re also talking several years before human trials commence. Ignoring the covid vaccine situation, which was driven by a concerted effort, globally financed and of benefit to everyone, the development and trials process is generally a long and very expensive one.
The other thing to consider is that with many new medications, unfortunately not everyone gets the headline outcome. Usually because our medical understanding is relatively basic in the grand scheme of things, particularly in relation to the role of genetics. We have personal experience of a drug that is considered miraculous and labelled life-changing, but having been available for a couple of years and now in widespread use, are one of about 15% of patients taking it that can attest to the fact that the effects are never guaranteed. That doesn’t mean that I don’t have hope whenever a new drug or breakthrough is publicised like this, only that I’ve learnt to temper my expectations. There are a great many hurdles to jump before a lab concept like this becomes a licensed drug.
It's all our hopes for a 'cure' but the reality is that these things take time and lots and lots of money; think how much covid vaccines costed to develop when the whole world needed it not a specific group of people mostly in the developed world. Sadly there are many reasons why it may never be developed including one that it course didn't actually work in people, another could be it was simply not effective unless a target group could be identified to administer too, and again it may get prove to have horrid side effects (think thalidomide which is still used today )but not for morning sickness. Personally I think I'll see a man back on the moon before I get a vaccine and in any event RA is not a death sentence for the vast majority of people it is an inconvenience not a disaster and they lead normal lives. Some of course don't but it may well be that this vaccine might if it did work, only work on one of the many different varieties of RA. Remember some test negative but still have the disease. Please don't think you can only hope for a cure, we all hope that but realistically remission albeit induced by drugs is just as good.
That's for sure. I'll take remission or a cure. With remission, though, aren't drugs still recommended?
Remission is because the drugs work RA is never cured like an infection. You take them forever. RA can wax and wain but unless the diagnosis is an error as far as I know you've got it for life. But why worry if the meds work ?
Guess I'd rather hope for a cure than take the drugs we take.
Wouldn't we all ! and I'm grateful for the medications that enable me to live a nearly normal life.
That would be so very welcome.xxxx
Yes that is good news but it will be many years before it is available.
How many years?
Who knows? My daughter in law has MS and when she was diagnosed, they said there would be a cure in 10 years. Still waiting!
• in reply toSheila_G
Same with CF, Sheila. We were told a working gene therapy was a decade away when my daughter was born. She’s 14 in a fortnight and they’re still saying it’s at least a decade away, although the foot seems to have come off the gas a bit with the breakthrough meds that have emerged in the last 5 years, even though not everyone with cf can have them, and not everyone that is eligible gets life-changing results from them 🤷♂️
Sheila_G• in reply to
I hope there is some good news for your daughter soon. Bless her, she is so young.
medway-lady• in reply to
I'm sorry to read your daughter has CF, I've had genetic testing and was told I have the gene ut its turned off so I was born with Cylindrical Brochectasis. That doesn't really do me much harm or hasn't yet but it does show how these things are being worked on and we just don't know unless something happens that brings it to our attention. I really hope your daughter is well and that a therapy that works for that is just over the horizon. RA is pretty easy to live with compared to CF and if focusing on serious conditions like CF brings better treatment then great.
Fingers crossed!
Wouldn’t that be a miracle!
Omg that would be soooo awesome, so amazing!!! RA is a dreaded disease ~ I never know when and where a flare up will occur ~ always afraid to travel too far as that's about the time one will occur
Thank you so much for this link!!
If you like to get technical, I just read this article about how the research for this vaccine was done and all the related details, which gives us more knowledge as to what's involved on a scientific level with RA.
pnas.org/doi/10.1073/pnas.2...
This next link talks about what's involved to get drugs approved. It has 2 large flow charts also.
ncats.nih.gov/translation/m...
• in reply toSpaghettiIsGood
I really hate to be ‘that guy’ again, but unless I haven’t understood the paper or have otherwise missed something, it doesn’t tell us anything at all about RA in humans. It does tell us something about artificially induced inflammatory arthritis in rats, and as it’s the full text of the original study you first posted about, it does give more detail about why studying the autoantigen in question may be beneficial for potentially coming up with novel ways to prevent IA in humans, but as per my original comment on this, it is only a may. The best we can say is that it provides some hypotheses regarding autoimmune inflammatory diseases that are worthy of further study.
What I did find quite interesting about this molecule is that it had no beneficial role in treating arthritis once it had begun. If it was ultimately found to have efficacy in humans against RA and/or other forms of IA, unless we discover a way to determine who will go on develop inflammatory arthritis in their lifetime, it would need to become part of the routine immunisation schedule to be of use. Unfortunately, though, that means that if the rat effects held up in human studies, it’s not going to be directly helpful to members here.
SpaghettiIsGood• in reply to
You wrote "it doesn’t tell us anything at all about RA in humans.". I thought it did, but I'd have to reread. And if it doesn't, it sure does go into the subject of one of the molecules associated with RA. Learning about that could be a springboard for discovery into RA, if one was interested. Anyway, isn't that how most developments start out (using animals)?
You wrote, "unless we discover a way to determine who will go on develop inflammatory arthritis in their lifetime,", I did read yesterday that something was or is developing to determine who will develop RA. Will post if found
Good luck in understanding this work as I don't but one thing I did pick up on this is not new as the link between the pANCA gene which I have and Vasculitus and RA. Its been known about for years so it may well be for just one type of RA. That might not prove to be your cure as you simply don't have that type. Please all the articles talk a lot about rats and from there to an effective treatment at a genetic level will take eons and in all likely hood will be cost prohibitive for the majority of patients be they on the NHS or in the USA and insured.
Many drug manufacturers make coupons and discounts available. I suppose they just want their drug to be used, whether we, or they, pay for it.
My first rheum said that to me about a medicine (the price was prohibitive) and it turned out there's a huge discount associated with it.
Why not go to the manufacturer's site and see if they're offering.
Hey, I'm with you; this stuff isn't easy to understand. After a while it's more familiar because you read other stuff you didnt understand. Sometime after you could say, oh, I've read that before and maybe make a connection or inference based on what you read before. (You wrote,"Good luck in understanding this work".)
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