Study finds inflammatory mechanism responsible for bone erosion in rheumatoid arthritis

[Hezekiah]

Only for those with a real love of dense medical language I fear

medicalxpress.com/news/2021...

(and no, I don't understand it either ! )

[AgedCrone]

Guess it just means don’t smoke?

[allanah]

Read it tomorrow , I've had red wine!! Night x

[Dspooky01 in reply to allanah]

Snap!

[allanah in reply to Dspooky01]

Have a lovely night 😂... lets talk science tomorrow !!

[allanah in reply to allanah]

Science is ..dont smoke with RA 😂😂

[Hezekiah in reply to allanah]

Science is.......don't smoke

[allanah in reply to Hezekiah]

😂😂😂😂

[MJSlide1958 in reply to allanah]

A good question: how much alcohol is ok to drink per week whilst on 15mg MTX tablets weekly??

[Neonkittie17]

I’ve seen worse! .. with the percentages and data splattered all over the page. I haven’t ever been a smoker but was a passive smoker as such at times as a child at home. I used to go out of the room from an early age but you may still absorb some as a kid.

[helixhelix]

As I read it, this paper is saying that, while they were looking to find out why smokers with RA tend to do worse than non-smokers, they discovered more about how at the cellular level the erosion process actually happens.

Just another piece of the jigsaw which could help find better solutions for us one day.

[RheumST]

They studied patients who smoke. If you smoke you should quit -even if smoking is said to be far more difficult to quit than many other addictive drugs.

Also, some medicines are specifically prescribed for certain types of Rheumy conditions (like mine for example, hence methotrexate) because they are supposed to prevent such joint damage.

Smoking is bad. Period. Fat around the organs is bad, not bad if simply below the skin.

Exercise is good, although perhaps not as enjoyable as eating, or smoking if you are addicted.

[Lolabridge]

Interesting. I do hope our Rheumatologists and the drug developers read it!

[Marionfromhappydays]

This is great, looks like smoking had highlighted a pathway they didn't know much about and its affects in triggering bone erosion in inflammatory arthritis;Now they know something triggers it they can investigate what will hopefully prevent it.

Immunology is so bloody complicated, but if they can find smoking (what specifically is it in smoking that causes this, nicotine or the toxic gases ??) Does this mean they are further down the road to finding what triggers our body to attack itself.

Our immune system is they key to alot of things, covid, cancer cures, autoimmune diseases I really believe one day we will find the answer. I also think alot more time and money will be put into research , look what they've done with the covid vaccine, gives me hope

[allanah in reply to Marionfromhappydays]

Me too particularly the messenger vaccines rma. So full if promise for other illnesses if you can teach the body to attack something, like cancers?!

[MJSlide1958 in reply to Marionfromhappydays]

My daughter's Rheumy has mentioned that smoking affects the efficency of a Biologic/Biosimilar.

[bienassis]

Just seen these posts, Hezekiah, and was interested in the article as I have erosions in my right knee. They were discovered in January 2020 from an X Ray. This was the first time that knee had been X Rayed since 1969 when I had the synovium removed. The disease was diagnosed in 1967.

As I understood the article, smoking does not cause the disease but exacerbates it. I have never smoked so I suppose I must look elsewhere for the trigger. Am I a boozer? Hardly, but I have read that that could also be the culprit. Passive smoking? Certainly; both my parents were chain smokers (neither had RA). And my childhood was spent in a haze of tobacco smoke in air raid shelters.

Perhaps it's treacle tart? Always been a favourite with me.

Cheers!

[Hezekiah]

You write very clearly and well, bienassis, so I'd say you have a rare gift. Sorry to hear about the erosions in your right knee, and hope they are not giving you too much pain or difficulty. Thank you for your "profile" which I read with interest, and amazement. I can vaguely remember treatment with gold (although I'd be hard put to have said for which disease(s)), but have never heard of Azathioprine. Amazement because of the many years during which the disease has affected you, and perhaps a still dawning understanding in me of history and age. I'm a mere stripling at 69 and a half which may be a generation, or a half generation, younger than you (albeit I never thought to use the term generation because it is less than specific, with all the potential inaccuracy of the claim that immigration will be limited to tens of thousands. How many tens of thousands - 10, 50, 200?). I'm guessing that if a traumatic event triggered your RA it may have been the birth of your daughter, although I don't suppose you would have any desire to link the 2 events as it might seem very ungrateful to do that. It was good to read that you had 10 years free of flares, that must have been a very welcome time for you. Anyways, I hope I haven't spouted any rubbish, or spoken out of turn, but I just wanted to share a bit of treacle tart with you. Cheers. Enjoy your gardening, and watch that sun.