I took lefunomide 10 mg for two weeks then had stomach problems and felt like I was burnt from my throat all the way down. I had bouts of nausea and headache too. I also had a cough. RA Doc. said stop taking it. Now I have to drink lots of water and be patient. This drug can stay in my system for three months. So much for trying a new drug. What is worse the disease or the drug???