Well I started on the Leflunomide on Wednesday, not expecting a quick change after the nurse explained it to be but I seem to be getting worse since I started it. All my joints are aching causing me not to sleep. Can't close my hand into a fist and one particular finger refuses to hardly bend. Taking some painkillers doesn't really help. Seeing the Consultant next month but getting so down about it. It's things like getting dressed, trying to close my bra, put on tights, close buttons. My husband travels quite a lot for work so is not always here to help. I am leaving work as I have said in previous posts that I just can't cope. Even though they know I am leaving because of my condition they still do nothing to make my life any easier. I get up earlier and earlier just to try and ease myself into the working day. I drive very little just to work and back as I don't feel comfortable any more. I am pinning a lot of hope on these working. I have to go to Berlin in December for a 4 night stay. It's my husbands 60th and it has been planned for a year with family flying in. I am dreading it now. When it was planned I was not too bad and could get around. Now we have all these sight seeing trips planned and I can't honestly see myself making them or else slowing the rest down. I am getting stressed over that which doesn't help. I just feel like crying with it all the time. It's all getting me very down . I am 57 but sometimes feel like my life is over. Moan over.