I had a depomedrone injection about two and a half weeks ago. It's the third time I.ve had one this year, but this time. I.ve become a bit too active and lively and almost sleepless for to or tree nights, with no feeling at all of tiredness . I know this isn't right and I need to be careful this new feeling of well being doesn't get out of hand. I guess asking for help to sleep might ne an idea, tho I don't like sleeping ills. I'm worried about taking my concerns to the gp as I find this med very useful, particularly as I cannot use any dmards for a few months till kidney issues with methotrexate get sorted out. What to do? Does anyone else feel a bit high on depomedrone?