I had depomedrone injection in my butt 3 weeks ago and I am wondering if anyone else has had rapid weight loss after the injection? I have lost a stone in 3 weeks. I was definitely quite puffy and had swollen feet so I guess it is fluid loss but I am quite surprised as I was told it might make me more puffy not less. I have had a fantastic response to it and am almost completely pain free and rushing around doing everything I haven't been able to do for the last 6 months but I would have to be running marathons to lose this this much. Just wondering...?