Its one week on now from taking an extra dose of mtx...taken by mistake ...prescribed omeprazole the day before so have taken 2x20mg omeprazole for one week.(supposedly reflux) Had contacted gp and rheumy nurse re extra dose and told NOT to take this weeks (thurs) dose of mtx . Immediately taking the omeprazole a cough appeared and I have been coughing up lots of flem which I put down to cause of the reflux...have been sweating and burning up for most of week and totally lifeless, initially my ra symptoms seemed worse and I was expecting even worse by missing this weeks mtx. The last couple of days RA symptoms seem to have eased but putting that down to perhaps taking co codomol for my temperature. Absolutley tired out, coughing all night with what seems like a bunch of feathers in my throat and sleep very eratic..as its weekend getting quite worried in case I have an infection (very hot , sweaty and weak). We are told with auto immune disease we need to be careful not to get infection, should I contact NHS helpline rather than wait until Monday to see GP. Any suggestions. Its all very very weird.