I have been taking methotrexate and humeria for about 18 months now with no side affects apart from slight nausea and associated stomach issues for 24 hours after I take the methotrexate. However for the last few months I have been experiencing night sweats. This is not just getting hot but about 30 seconds after I wake enough to turn over in bed a wave of heat spreads though my body and I end up lying on top of the bed for a few minutes until it subsides. Seems to be getting worse and more frequent and should probably go and see the doc but wondered if anyone else experiences this and it could be a side affect of the meds. I should state that I am male and certainly not menapusal!