I've had Fibro for 25 years , and last year found out I also have RA. For the last year I've been working with my doctor to get my RA under control. Started out on MTX , folic acid, and prednisone . I stopped the prednisone after the MTX started working. It was helping a lot with my pain and stiffness. Just had a problem with feeling really tired, real heavy and unsteady ! About 2 months ago I had to go off the the MTX because it was causing liver problems. I was off for a month, and was just taking prednisone and tramadol until my liver recovered .And was feeling so much better While I was off the MTX .So much energy and not having that heavy feeling. Then I Started on Leflunonide and about a month on it I started feeling bad again with the tired and heavy unsteady feeling!! I couldn't take it any more and called my doc . And he had me get some blood test to see what was going on. He told me that the test showed that I have Epstein-Barr Virus . And that I needed to go off the Leflunonide so my body can fight off the virus!
He said that most people have this virus and that taking the RA meds that lower our immune system can bring it up in some people! So I'm thinking that the MTX was causing the problem to start with. And while off it for that month I got feeling better because my immune system was fighting off the virus! Then when I started on the new Leflunonide meds it came back . So right now I'm just taking the the prednisone and tramadol . I'm getting another blood test in a month!! And not sure what the doc is going to do then! Has anyone else had this kind of problem before???Thanks , Gingeq