Hi out there. Wondering what sort of experience anyone has had when tapering their prednisolone dose. I have been on them for 24 years on varying doses and alongside many other drugs. Recently, because of problems with Rituximab, they are now the only barrier I have against my disease. My consultant is keen to get me on the lowest dose possible and I'm reducing from 7.5 over two months to 5 mgs per day. I'm in the sixth week of this but it's been a struggle and some days I've felt really unwell. Achey, stiff and painful and really arthritic. I'm guessing tis is due to my adrenals having to re-set but would be interested to know if anyone else has had this happen. Lots of thanks and look forward to any replies.