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Help please

I am on Methotrexate 15mg, Sulfasalazine 500mg 6 tabs p/d,Leflunomide 10mg 1p/d, Tramadol 50mg 2x3 p/d, Propranolol 80mg 1 p/d, Cyclizine 50mg 1x2 p/d, Folic acid 5mg 1 p/d for 6 days, Sertraline 100mg 1 per day, Lansoprazole 30mg 1 per day, Symponi (Gollimumab) monthly, Vitamin B12 boosters.

I have Rheumatoid arthritis osteo-arthritis and psoriatic arthritis diagnosed from Nov 2011.

I am Vitamin B12 deficient.

I am overweight as I cannot be as active as I would like to be.

I am depressed & suffer anxiety for the past year or so..

.Lately my husband is saying I a groaning in my sleep for the past four weeks he is also my carer. I am not aware of myself groaning but my husband is pointing it out to me saying that I could be doing it to deprive him of sleep. He has even woke me up by pulling the pillows from under my head thinking I`m on a mobile phone because it the groaning sounds like I`m talking but in reality I am asleep. We tend to go to bed usually around midnight to 3am.

I am at times exhausted tired irritable. Could all the medication I am on be affecting me in various ways.

I am in some way in pain throughout my body worst is hands legs hips shoulders. Anyone advice would be helpful please. Thank you

7 Replies

Hello Stiffenlady, and welcome (I think you are new here?).

Whilst I can't help re the groaning you mention, I wouldn't be at all surprised if the cocktail of meds is having an effect on things generally. I too take multiple meds and have taken some of those you mention and I have had all sorts of weird and wonderful symptoms which seem likely to be caused, at least in part, by all the meds. I'm so sorry you are still in so much pain, despite all the meds and I wonder if the groaning in your sleep is because you are in pain and aware of it, even though you are sleeping. I know that sometimes, when I wake up in pain, I realise I have been dreaming that I am in pain so I think it's possible to be aware of pain even when we are asleep if that makes sense. I'm also not surprised that you feel tired and irritable - being in constant pain and/or always unwell can be very wearing, I find and it can be very hard not to get depressed or to be irritable with those around us, no matter how much we try to do otherwise. You are going to bed very late by the sound of it too and I don't know what time you get up in the morning but maybe if you are not sleeping for long enough, that isn't helping (although I know too from my own experience that it's not easy to sleep when unwell or in pain). I know that I tend to delay going to bed because I know that going to bed earlier might mean I just wake earlier in the night but I'm not sure I do myself any favours by going to bed late. Because my husband and I tend to disturb each other I have found that by going to bed before he does, hopefully I am asleep before he comes to bed and that seems to make for a better night for both of us. I don't know if any of that is helpful, but please know that you are not alone in your struggles - I know others will relate to your situation too and hopefully someone might have some other ideas which might help you.



Oh my dear?..I am sorry to hear all of are on an awful lot of meds...there are people on here who know far more than I and I'm sure these lovely people will give you advice..I just wanted you to know I am thinking of you...someone on here will help you I'm sure...sending you warm wishes. Maryx



Looking at your medications, I would recommend, strongly that you contact the RA Nurse and GP.

Because of this script I am unable to advise, All I can say is the list seems to me far to extensive



Hi Stiffenlady

Disturbed sleep is the worst thing, I always think, because it has such a knock on effect of the rest of your life and your wellbeing. I had terrible problems with sleep for a long time. Part of the fix for me was to make my bedroom really warm and cosy and a nice place to be, then to go to bed really early. I didn't necessarily go with the expectation of sleeping, but to read and listen to the radio, sometimes watch TV on my laptop (though people usually recommend against TV because it makes your brain fizzy!), catch up with e-mails/Facebook - generally quiet relaxing things. I used to take a tray with a warm drink, and also my toothbrush and a glass of water so I didn't have to get up again. That all meant that when I did get off to sleep I was much more likely to stay asleep - far better for me than the napping on the sofa/waking up cold/uncomfortable/unable to get back to sleep cycle that I had got locked into. Also, if I did wake up again, I was surrounded by relaxing things to do in the night so being awake didn't feel like a torment - though I sleep on my own, so there is no one else to disturb if I decide to listen to the radio at 3am. Essentially I made bed a really pleasurable place to be, which removed some of the not-sleeping anxiety. I don't know if any of that would work in your circumstances, but I hope you can find a solution for you, because disturbed sleep is so horrid.

Good luck,

Dotty xxxx


Do you have a spare room! I resort to that to let hubby sleep and I can toss and turn as much as I need! Or get him some ear plugs!

Also I would call your Rheumy helpline too, if you are groaning with pain even when asleep maybe they need to review your meds or pain relief?

Hope you feel better soon Ax


Hi, sorry to hear that you are in so much pain.i thought you couldn't take methotrexate and leflunomide at the same time?but I'm no doctor. I think you need to see your GP and see if they can sort your meds out cos you are on a far whack already and it's not working.there is a lot of other anti inflammatory meds ,pain and sleeping tabs out there you can try-don't give up.perhaps you need to make an appointment to see Rheumy too ASAP.

As allanah said do you have a spare room you or hubby could use in the mean time?

Hope you feel better soon xx


Think you could probably do with a prescription review at the doctors, or even the pharmacist offer this now


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