I was looking for MTX nausea info and came across this RA blog where someone had written this as part of a bit of disagreement on what was causing nausea. It made me wonder anew. I've been taking 5mgs daily for 5 days per week and when I asked my pharmacist and GP they both said you couldn't O/D on Folic acid but the side effects described sum me up to a tee?
"Sorry, my pharmarist told me not to go over 1mg. I did some further research and found this on drugs.com"
"Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic Acid daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgement. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic Acid therapy."