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SWITCH - research study for those on 1st anti-TNF and methotrexate

Do you suffer from Rheumatoid Arthritis (RA)?

Are you currently receiving a first anti-TNF treatment?

Would you like to be involved in a research study?

Male and female volunteers aged over 18 are required to participate in a research study on Rheumatoid Arthritis called SWITCH. This research is important for the community and will provide us with new information on how best to use the treatment options available for RA patients whose symptoms are not improving with their current anti-TNF treatment.

If you have been diagnosed with RA and are currently receiving a first anti-TNF drug (e.g. Remicade, Enbrel, Humira, Cimzia & Simponi) together with methotrexate then you may be suitable to take part.

The study will compare three different treatment options that are available to patients who are not responding to their current treatment. You will receive one of these options, although neither you nor your doctor will be able to choose which you receive.

You would be involved in the trial for up to 96 weeks and the number of visits you would attend would be similar to that in routine NHS care.

If you would like more information about the SWITCH study, please visit:


Many thanks


NRAS Membership Supervisor

2 Replies

Hi Emma,

Reading your post , I'm confused as to whether u need to have started your first anti tnf and it not working?

I started cimzia June 2013, but had been on enbrel for a month. Came off due to reaction to enbrel.


Hi Case,

I suspect as you are on your second Biologic you may not be eligible however it might be worth emailing the organisers ctru_switch@leeds.ac.uk to confirm this.

Best wishes



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