I've now been on the combination since Jan 10th. Solid update. It has been 78 days since my last phlebotomy. My HCT has been 38.8 3 weeks after, then 41.1, now 43.2. So trending higher.
However, my MCV has been driving this increase and has finally become normal for the first time in years. Here's a picture of my MCV:
My RBCs continue to drop, perhaps at an even more accelerated rate due to the Jakafi. I guess I can't post 2 graphs in the same post so I'll post it as a response. In short if the MCV can stabilize soon then perhaps my HCT can stabilize soon. I've had an increasing MCV for a couple years as my body adjusts to the Besremi.
My WBC also remarkably rebounded to 3.51 up from 2.83 and my ALT and ASTs also both improved and are either just barely above or within normal range. Lymph also improved from 0.66 back to 1.00, highest reading since September despite adding Jakafi (though within the normal volatility I've seen). Neuts have held steady falling from around 3 to 1.66 back now to 1.77. Platelets 164 --> 168.
Overall, I'm optimistic I can drive improvement in my HCT and hopefully avoid a phlebotomy for some extended time. I did get a scare from the derm when I misread a mole removed that came up positive for Melan A. I thought that was Melanoma. 24 hour roller coaster. This all still suggests to me for those unable to stabilize HCT with just Besremi, a combination of both therapies appear to accelerate improvement.
