I have a possible Crohn’s Disease diagnosis after an endoscopy on Monday showed a 7 cm ulcerative patch in my lower oesophagus. My Consultant thought malignant but managed to get the biopsy results on Wednesday and suspected Atypical Crohn’s.
Need a Pet Scan to confirm.
My concern is that Crohn’s is usually an autoimmune problem and I really don’t want to stop Besremi as this is controlling my PV.
Does anyone have Crohn’s but been able to continue with Pegasys/Besremi?
Thanks Paul
Hey Paul... 
Long time since you & I have shared a conversation etc...
BTW, I am sorry to learn of this new development for you, or that you are possibly now having to add to the mix of associated MPN complications ...
Showing yet again that MPNs are truly alike the immortal words of Forest Gump's descriptions of a box of chocolates...
Unfortunately, I cannot shed any helpful light at all for this Q & A, as I am not even managing my Post ET / MF w/ Peg' but rather Rux'.
However Paul, I will be intrigued to learn from this question of yours too...
You suggest via your question that having an "autoimmune" diagnosis (Dx), then precludes one from being able to utilise 'Interferon' or "Besremi".
I was not aware that complications like this were extant at all...
Please forgive my ignorance here Paul, but are you also aware as to "Why?" That
Interferons (Besremi), are not able to be used when a person is also afflicted w/ an "autoimmune" Dx?
In my own assumptions, I was tending to be of the opinion that many people w/ an MPN also had other "autoimmune" complications to contend w/ too...
Anyways, again Paul sorry to learn of this further development on your MPN journey...
Best wishes my friend...
Steve
(Sydney)
Thanks Steve, good to be in touch again.
My understanding is that interferons can, in some cases, cause autoimmune issues. Particularly after long term use, I’ve been seven years. So it’s possible that Besremi is aggravating the Crohn’s, assuming that’s what I have.
Equally worrying is whether the Besremi is causing autoimmune issues since I really don’t want to stop it.
Hope you are in good health. I’m afraid I don’t monitor the forums as much as I should, a case of whilst I’m stable, I’m just trying to forget about my MPN.
Very best wishes Paul
Understood, that's often the best thing one can do... 
Anyways, do let us know more as things progress...
Steve
Was your new condition sudden? You're right to be concerned about a possible auto immune condition arising while on IFN. Do you expect to find out more on the Crohn's being an autoimmune type?
The problem is what any of us have experienced may not predict what you will experience. Odds are all is ok, but there is an increased risk of a bad outcome, possibly sudden, and IFN can be most unpredictable in this and other areas.
What is your current dose? You could ask your Dr about reducing it and maybe combining a low dose of Rux. This may reduce the risk although it did not for one member.
I just found a document in my collection with this, and other relevant details:
"thus, if patients have high levels of serum gammaglobulins prior to treatment, or they develop increased levels of gammaglobulin while on treatment, clinicians should then consider the possibility that the patients may develop an autoimmune disorder."
pmc.ncbi.nlm.nih.gov/articl...
You should ask your Dr about getting an immune panel, I listed the extensive tests I got in post a while ago.
Besremi and Afib
Besremi and Hematocrit Control
New to MPN Voice
