Edoscopy Results ; Anyone share their experience or advice please?

[Threelions]

I’m ET J2+ & have been on peg & daily asprin since diagnosis c 4 years ago (also take statins & perindopril)

I had been suffering from excessive heartburn & stomach/chest pain in the last 12 mths + & MPN team referred me for an endoscopy.

Results confirmed Reflux Oesophagitis & Erosive Pan Gastritis.

Appreciate it’s maybe not connected to MPN but wondered if anyone else has suffered with this & maybe if my regular MPN medication may have contributed to it ?

I’ve been prescribed PPI & anti H2 so hope they will sort it out & not interfere with my regular MPN medication.

In all honesty these oesophageal issues have been far worse than any ET symptoms I’ve experienced.

Thanks to my lovely fellow MPNers in advance for any info/experience sharing👍 x

[Cat1001954]

I’m on lanszoprozole and take hydroxycabamide no problems it’s a relief from bad reflux

[Threelions in reply to Cat1001954]

Thanks Cat,

Really appreciate it. 👍

[Cat1001954 in reply to Threelions]

Your very welcome

[HazeBlue in reply to Cat1001954]

Me too

[hunter5582]

I also have GERD, a Hiatal Hernia, and periodic issues with esophagitis. I have been on a PPI for many years. While not directly related to the MPN, there is a central theme of inflammation. The JAK2 mutation causes an increase in inflammatory cytokines. This can contribute to a variety of symptoms and has the potential to make "unrelated" conditions worse. The injury caused by the reflux can also trigger reactive thrombocytosis. While the GERD and MPN are caused by different things, they have the capacity to interact with each other. Our bodies are integrated systems. This is part of why holistic care is so important.

It is possible that the aspirin and Pegasys may impact the symptoms you report. Pegasys can cause nausea and vomiting. Aspirin is well known for its potential for GI irritation. This would be an issue best discussed with your MPN Specialist.

Wishing you all the best.

[Threelions in reply to hunter5582]

Hi Hunter,

Sorry that you suffer from those issues but most grateful, as always, to you for sharing your experience(s) & some of your wealth of information & knowledge.

Whilst writing, I think I speak for every one of us in this group, in offering you sincere thanks for the time & effort you put into responding to our qs & worries.

You really are the foundation rock of this group & we’re all very grateful to you. Xxx

[hunter5582 in reply to Threelions]

Thank you for your kind words. I get a great deal out of participating in this forum. It is one of my main sources of support in managing what we experience with MPNs.

[Carol0925 in reply to Threelions]

Hello, just a thought is your Aspirin enteric coated? I used to have reflux issues, so requested enteric coated aspirin, I’ve had no problems. Hope you find a solution.

[Threelions in reply to Carol0925]

No they’re not. Never thought of that but a super suggestion. Thanks very much.👍

[william-Indo]

Ask your doc to change your aspirin to clopidogrel.

Avoid acid or spicy foods, dairy products, flour products and coffee etc. until the simptom disappear.

Most important, do not stress

Hope it may help.

Cheers

[Threelions in reply to william-Indo]

Hi

Thanks for the advice. Have been avoiding acidic foods & don’t have caffeine but wasn’t aware that flour products are worth avoiding 👍

[Lifam]

I have reflux and very sensitive stomach, when I was first diagnosed i was on asprin apart from hydrea. Was on asprin only 2 weeks and my stomach hurt so much. My haematologist then prescribed me Clopidogrel, that solved the problem. I've learned that asprin not really for everyone. I've been taking Clopidogrel ever since. May not be the same to you, may worth to find out from your haematologist.

[Threelions in reply to Lifam]

Never heard of Clopidogrel. Will ask about it on next appointment 👍

Thank you.

[Ovidess]

I have PV, diagnosed at the end of 2022, but my GERD nonsense has been going on at least a decade, I think. I use a PPI when it gets out of hand, but certainly suffer when I give in to some favorites like coffee, dark chocolate, spicy food, oily food, etc. It can be quite intense, perhaps more so since taking Besremi. Not sure about that. When it is bad, it can feel as if there's no room for food to go down into the stomach, as if the esophagus is a one way street going the wrong way.

[Threelions in reply to Ovidess]

Very similar symptoms here &, as you say, not pleasant. Hopefully it’ll get better with the prescribed medication & some of the suggestions here👍

[RietFontein]

Hi ThreelionsI have been on PPI (rabeprozole) now for more than 8 years (reflux). Diagnosed with Chronic Myeloproliferate desease 18 months ago. Using Hydrea since diagnosed with no problem or interaction between drugs.

Be safe!

[Threelions in reply to RietFontein]

Cheers for sharing, much appreciated.

Wishing you all the best 👍

[LeoTravels]

Hi from Australia,

Apart from anything else, Asprin will cause Gastric distress and I have to take Somac to counteract that every day, have done for years.

Many of us are in the same boat and my only advice is to speak up and request that all symptoms and effects of medications are treated. I had 7 specialists at one point treating the symptoms of the same disease. Unless you ask I find you don’t get all of the information you need. It’s a balancing act x

Best wishes to you xx

[Threelions in reply to LeoTravels]

Thanks Leo

Much appreciated 👍