I just got a vitamin B6 result 4.5X over upper limit. I saw a post on Quora from a Dr stating PV can cause this. I find no supporting reports anywhere.
Are there any members with high B6 not on B6 containing supplements ? It supposedly causes neuro troubles.
Several of the supplements I bought (e.g., magnesium) contained vitamin B6 and it was not easy to know, given the label was Magnesium, and vitamin B6 (400% of DRI) was barely mentioned somewhere in small writing. I took that supplement for 2-3 months and when ordering it again from the pharmacy I saw their updated contents on the website and the vitamin B6 presence, so I stopped taking it. I did not notice any neurological issues in that period, but probably it was just luck.Some other supplements literally contained B6 without even mentioning it.
I noticed that some beverages and even some power bars had vitamins included, which is beyond their purpose, but some companies can add vitamins to drinks and even some foods.
As supplements are not regulated, they might not specify everything on the label. Some have a proprietary formula, which means they do not have to disclose the exact content, they just have a fancy name for a concoction that might include vitamins.
Another possibility that is worth investigating is potential autoimmune disease.
I hope you find what is causing your elevated levels of vitamin B6.
I just found one guilty party. Melatonin. I take just a half pill, but it works out to 300% RDA of B6. I didn't give it a thought till this test came. I agree with your comment "beyond their purpose". No doubt there are other B6 spiked foods and meds lurking as you found.
On the A-I disease, that is what controls my life these days, but a search brings up association of low B6 with Sjogrens. That would be nice, it's easy to add salt to the soup, but no so easy to take it out.
Somehow my neuro is ok by Sjo standards, hoping the B6 dissipates before it kicks in.
It is good that you found the culprit. Someone else I know ended up at the neurologist thinking they have MS, and they discovered there was 2000% DRI of vitamin B6 in a supplement they took that was not straightforward about its content (not mentioned on the bottle, just online on the page of the product on company website).
You should be OK once you stop taking the supplement that gave you this increase in vitamin B6, especially since it did not give you neurological symptoms yet.
As someone who had bouts of autoimmunity, I understand your being careful to not take anything or do anything that could trigger a flare or worsening.
I have never heard of PV being related to elevated B6. Suggest a prompt follow up with your care team if this finding is confirmed.
Good Morning,
I don’t have supporting evidence, my B 12 level at initial lab appointment was over 5000. Oncologist stated caused by my MPN, I am Essential Thrombocythemia or as specialist calls it PreFibrotic Myelofibrosis. Told me he would give my IV B12 if he felt like I needed it, but doesn’t think I can utilize it. Interestingly, I want to have it measured again out of curiosity. Have now been on Besremi almost 2 years.
If you have opportunity to ask, it would be good to know where your Dr got that connection. A quick look, B12 is less prone to toxicity than B6. If your B12 was too high, why would your Dr add more via IV? Maybe poor absorption?
Did you get B6 measured?
Specialist acknowledged we would have high B12 level if taking oral supplement, which I was at the time. did not have B6 level done. Stated can’t be utilized in oral supplement. Sorry left that part out. Basically acknowledging the tiredness people experience maybe related to lack of absorption of B12 when taken orally. I will clarify and do a post end of October when I see him. The PA or NNP did not know. I failed to ask why he would think IV version would be absorbed. I was just thinking, IV vitamins sounds expensive and doubt insurance will cover that. So didn’t even at the time ask, later did ask Assistants and they didn’t know.
IV B12 is common at integrative medicine practices. I went to one and got messed up from a different medicine. But infused B12 is well established and should be covered if your regular doc orders it.
In this report IV was better absorbed than oral, see plot:
ashpublications.org/blood/a...
A shot might give longer lasting effect but lower levels:
"So, B12 injections can last for one month with slow release into the blood. In contrast, an IV (intravenous) infusion gives you the dose immediately so that you get the benefits immediately, and the effects are shorter lived. "
integrativemla.com/blog/b12...
--
From my fresh experience I suggest everyone should also ask Dr about a B6 test, esp if one has any neoro troubles. It's in so many supplements and foods and can be toxic. I never had before this test before.
Thank you very much for adding to my MPN knowledge once again. I have not experienced issues nor have concern yet about B6 nor B12 but now understand how important it is to be aware. I share these tidbits with my hematology support team who appreciate the updates, too. Thank you for helping hand.
Thanks for that info EPguy 😊
Your situation with elevated B levels is so interesting. My cholesterol panel is somewhat normal but I always have semi-hi Triglyceride levels (170) with low HDL. I started researching this and have found that chronic inflammation conditions can cause readings of high Triglyceride and low HDL levels. It's so frustrating having PV and not knowing if it can cause other problems or skewed blood results or figuring out if it has anything to do with PV. I'm going to ask for that inflammation CRP test at my next doctors appt. as well as a vitamin profile. Hope you figure out the high B results. Best of luck. Kerry
According the Gemini (AI); «While there isn't a vast amount of specific research linking high vitamin B6 levels directly to polycythemia vera, several studies have explored the relationship between vitamin B6 and other hematological conditions. Here are some relevant references:
* Vitamin B6 and Erythropoiesis: While not directly related to polycythemia vera, this study explores the role of vitamin B6 in red blood cell production, suggesting a potential connection to conditions like polycythemia.
* Reference: J Nutr. 1998;128(11):1950-1956.
* Vitamin B6 and Hematological Disorders: This article provides a general overview of the role of vitamin B6 in various hematological disorders, including anemia and polycythemia.
* Reference: Clin Nutr. 2006;25(2):168-176.
* Polycythemia Vera and Vitamin B12: While this study primarily focuses on vitamin B12, it also discusses the potential role of other B vitamins, including B6, in polycythemia vera.
* Reference: Am J Hematol. 1982;12(4):413-420.
It's important to note that while these studies provide insights into the relationship between vitamin B6 and hematological conditions, more specific research linking high vitamin B6 levels directly to polycythemia vera would be beneficial »
Level blood plates
Low PH level?
Fatigue and Itching
High platelets
high platelets 
