Vit D and platelets

[jodary]

Just read an interesting item regarding vit D deficiency and platelet count. I was actually trying to research whether it could make any sufficient difference to the blood result depending on the time of day the blood was taken. Or even if morning or afternoon would affect it. I usually have afternoon blood tests but have just had an early morning one done.

[hunter5582]

Very interesting. I am chronically Vit D deficient due to NF1. I take 3000iu daily just to stay in the normal range. Did the study indicate what dose of Vit D was used? Or was the issue to resolve Vit D Deficiency?

[jodary in reply to hunter5582]

pubmed.ncbi.nlm.nih.gov/345.... Trying to copy the link. Not sure if it will work. I've googled Vit d and platelets and there's a few references. I was curious as my Vit D is also abysmal and I've been supplementing for about 3 months now and have just had my first blood test since beginning D3 supplement, will get results on Friday.

[hunter5582 in reply to jodary]

I got curious and found the full article.

jcpsp.pk/article-detail/vit...

The theory is that restoring normal Vit D levels reduces the inflammatory environment. Since we know that inflammation drives thrombocytosis up, that would make sense. It will be interesting to see if this is replicated.

I do believe strongly in basing these kinds of interventions on solid science. I take Vit D because I have a measured deficiency. In my case it is related to the NF1 mutation that I also have present. I triturated the Vit D dose by measuring it after I initiated Vit D supplements. I think it is best to measure the things we can measure to ensure we are on the right path.

Thanks for posting this very interesting information.

[jodary in reply to hunter5582]

I suppose I am searching for something to make sense of our mpns. My vit D was 39 ( range 50 -150) so I was interestedto see if I improved that , would it affect my platelet count. I have a telephone appointment on Friday so will be interested to see if my supplements have had any effect at all .

[hunter5582 in reply to jodary]

We can only hope to make sense of it all. I do believe that our bodies are integrated systems. There are many things that are related in ways we do not always understand. To paraphrase the old song "the blood bone is connected to the gut bone..."

[Mostew in reply to hunter5582]

Thanks . That is interesting. I've been low and took 4000iu. For several months now taking couple of times a week .

[Amethist]

I discovered this a while back and asked an MPN specialist about this. Unfortunately she didn’t know anything. There are several papers indicating both platelets and megakaryocytes have vit D receptors, so clearly vit D is very important here.

[Yeswithasmile]

Hi Jodary

My mum takes hydroxy and was told that she mustn’t supplement vitamin d because of this. May I ask what medication you take and if anyone else has actually been told this??

I was surprised to read your post and replies as obviously vit d is very important especially with more and more research coming out on it since Covid.

Thanks.

[jodary in reply to Yeswithasmile]

Hi, I take hydroxy and have been told to supplement vit d as mine is so low. Also we are advised not to expose ourselves to the sun and to use sunblock because of the skin cancer risk. So completely the opposite to your advice.

[Yeswithasmile in reply to jodary]

Thank you very much Jodary. Your reply is much appreciated.

[jodary in reply to Yeswithasmile]

I know some D3 supplements contain vitamin K, this is supposed to direct the vit d away from organs etc and to bones. I wonder if it's the vit k we are supposed to avoid. As I believe it plays a part in clotting.

[Hello94 in reply to jodary]

If you are taking Higher amounts of Vitamin D over 5000IU you need the K to prevent the D from pulling the calcium out of your bones. K should be I believe 100mg. I am not a doctor, just what I have read. If anyone could clarify that would be great.

[jodary in reply to Hello94]

I tried to find out if people with mpns could take vit k, as I thought it had something to do with clotting. I asked on my last phone call appointment but the person I was speaking to wasn't my consultant and was not helpful.

[Hello94 in reply to jodary]

Jodary, I found a link talking about Vitamin Kncbi.nlm.nih.gov/pmc/articl....

[jodary in reply to Hello94]

I am a bit confused now , maybe I should be taking a D3 supplement with vit K. I will try and ask at my next appointment thank you for this x

[ciye in reply to Yeswithasmile]

I was sent vitiam d to take over the winter by the hospital,

[jodary in reply to ciye]

Very confusing conflicting advice as appears to be so common.

[Yeswithasmile in reply to jodary]

As with so many things. Thank you everyone for your input.