To antivirals or not to antivirals

[flamboyant_hawking]

ET with CALR, on warfarin and 45mcg Pegasys every 4 weeks. 3 vaccines, last one in November.

Just when I started hoping I was going to remain one of the few... COVID got me. I brought my dogs on a long walk on Friday and was convinced I cought a hay fever ln Saturday... as my nose was blocked and I was sneezing from time to time, decided to test and voilà! I registered the result and expect to be contacted tomorrow.

Last time I talked to my (great, caring and reliable) hemo, she wasn't too worried about me getting Covid.. I have no other simptoms, so I'm wondering what should I do if they offer antivirals. Do we even know if they clash with the interferon or the blood thinners? It will be day 4 tomorrow, so I'll need to act quickly.

[hunter5582]

Sorry to hear about the COVID. Suggest reviewing your question with your provider. you can also check here.drugs.com/drug_interactions...

online.epocrates.com/intera...

I did opt for monoclonal antibody tx when I had COVID back in January. Was on Pegasys at the time. no issues with it.

All the best. hope you feel better soon.

[Mazcd Partner MPNVoice]

hi Flamboyant_hawking, so sorry to hear that you have caught Covid, with regards to any interactions with your MPN meds, the CMDU will ask you lots of questions about your MPN and the medications you are on and will advise you accordingly. Best wishes, Maz

[flamboyant_hawking]

Nobody contacted me from the NHS, so I contacted everyone.

111 booked antiviral infusion for tomorrow, as the pill interacts with warfarin.

Meanwhile, I got the response from my hematology department, saying that although "there is little data to guide decisions" (it's hard being so niche, guys!)... they don't consider ET nor Pegasys particularly immunosuppressive, so they don't refer the patients of this profile for antiviral therapy.

I have more trust in hematologists, but also worry about the possible worsening of the symptoms and wonder if AVs might prevent long Covid or other long-term consequences...

[EPguy in reply to flamboyant_hawking]

A spot of positive is the current variant, Ba2, is not as threatening vs earlier ones for those vaxed and boosted. But as always nothing is 100%

But ba2 also requires the correct type infusion as many of the prior available antibody treatments are less effective against ba2.

[Wyebird]

I’m on peg. There was a covid update via Guy’s MPN support team. It stated how to get your antivirals should you get Covid. Nothing was said about not taking it.

[Wyebird]

You, I think have to contact NHS to get the antivirals