Combined antiplatelet and anticoagulant therapy for ET clot prevention.

[SilverET]

Hi All,

Has anyone had experience with combination therapy for prevention of clots with ET or PV? I was switched from Clopidogrel to Apixaban after a suspected mesenteric clot and ischaemic bowel bleed. I had been stable for a long time and platelets still just over normal levels but something changed and problems started to arise.

The switch to apixaban seemed ok at first once I got used to it but then I started having periods of platelet showers ( still not remarkably high numbers) and symptoms of TIAs. I am now trying apixaban and clopidogrel combined. This will increase my bleeding risk ( esp with gastric varicies from a previous portal vein clot when I was a teenager) but I can’t wait for a major stroke event so here we are. My haem said they are now trying apixaban and drugs like it with aspirin in a COMPASS trial with success but wondered if anyone with MPN has experience with it? I am suffering some side effects today but it is day 1 of combined so they may settle with time. Any experience or advice on what to watch for welcome. My haem is good and I have his mobile for any concerns which is very good of him.

Hope everyone is maintaining an MPN balance at the moment.

SilverET

[Rachelthepotter]

Hi. I’ve been on rivaroxaban ( its a once a day drug) as an oral anticoagulant for 5 yrs or so: I had a pulmonary embolism before I was diagnosed with MF.

Very occasional nose bleeds, but no real probs.

R

[SilverET in reply to Rachelthepotter]

Hi Rachelthepotter,

Thanks for the info. Do you also take an anti platelet drug or aspirin as well as rivaroxaban?

Regards,

SilverET

[Rachelthepotter in reply to SilverET]

No : the rivaroxaban seems to do the trick and keep my platelets OK .

R

[socrates_8]

Hey Silver ET ...

Do keep us all Posted as to your latest evolution with this new combination therapy etc...

Best wishes

Steve

[SilverET in reply to socrates_8]

Will do, Steve. Hoping it’s the silver bullet. Ha! See what I did there?

Yeah I know. It’s terrible but need to laugh.

[socrates_8 in reply to SilverET]

Very clever indeed...

Keep smiling & stay positive as always...

Steve

[nivana]

I have also been taking rivaroxaban daily for 3 years following a pulmonary embolism. Have had no problems with it. Stopped taking aspirin when started the rivaroxaban. Kind regards