Fast COMT Val/Val: Anyone dealing with... - Major Depressive ...

Major Depressive Disorder (MDD) Support

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Fast COMT Val/Val

Sparks1230 profile image
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Anyone dealing with depression ever get tested genetically and find you have FAST COMT Val/Val. This gene allegedly leads to low dopamine and low norepinephrine in the brain. My symptoms have always been low energy, slow cognitive tempo, brain fog, low mood, poor recall memory, poor motivation (unless I’m interested then I’m all in at that time). I am currently struggling. I’m trying to see if there is a link betweeen this gene polymorphism and depression that presents itself with what I understand to be low dopamine symptoms. I’m trying to find the right treatment. My psych isn’t putting much thought into this. I feel there is a link and I wanted to know if anyone has found this to be true. I appreciate any help. I am struggling right now and have for some time and I’m just looking for answers.

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Sunnyday100 profile image
Sunnyday100

yes I had the. As it turns out it validated what was happening to me there is a pathway called a P450 and mine was blown. It is the pathway that helps to process serotonin and other modulators so although they were pouring in the, I wasn’t really getting any better because my P450 pathway was blown.

The test helped me understand that this was my programming Not a flaw, but an actual genetic program that my brain was also helped the doctors to identify drugs. That work better for me that could avoid using the50 pathway. The Doctor Who ordered the genome test was brilliant for doing that. I still look at my every now and then and I was very lucky. Insurance did cover it but they do have discount cash prices.

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