I have been having terrible side effects to my methotreaxte, mainly bad nausea,weakness, and a fussy feeling in the front of my head, like glazy feeling. I take x 10 weekly. I spoke to my Rheumy yesterday and for interest sake to all, he told me that i can split my dose and take it over two nights. I am so happy and trust this will help me as I really suffer for 24 hours after taking my methotrexate. I eat salt n vinegar chips for two days and toast as cant take any food in. I seem to crave vinegar foods when feeling so bad. Any feedback would be appreciated. Have a Blessed day further and lets live every day to the fullest as we dont know what the morning will bring. Blessings!