hi. all i have a ? sle/connective issue diagnopsis and been on plequnil and steroids for years. over past 6-9 months my steriods have been upped then lowered to try to manage fatigue ect. this is the worst period i have had in 10 years. when my steriods have been upped during this 6-9 months i have found i am getting alot of infections that make me feel really ill. the anti biotics also make me feel ill to-sick ect. i am due back at the rheumy in a couple of week s and feel my medication need s sorting as i am in a catch 22 situation. the clinincal nurse has mention low dose immuno suppressants . taking these woiuld mean i can lower steroid dose she thinks. can you please give me some advice regarding immuno suppressants and you personal experinces. although i am very symptamatic of sle my bloods have never been totally positive.