Has anyone else had a Systemic Response while taking Lansoprazole?

[Cardih]

I had a nightmare of a time for a few months with it, after 6 months of use

[panther50]

That’s interesting. My GP went through omeprazole, then lansoprozole, then pantoprazole as we struggled to get my gastric pain under control during a major flare. We tried v high doses too. I can’t say if it caused the flare as I was already in one, but maybe it didn’t help. Pantoprazole seemed to be the only one that worked, but we were never sure if the gastric inflammation was part of the flare up. It improved as all my symptoms improved. Sorry this doesn’t really answer your question. 🤔

[Cardih in reply to panther50]

Hi Panther 50

Thankyou for replying

Yes I went Omeprazole 40mg which i saw awful side effects of, gastro then changed me to Lansoprazole 30mg.

This at first gave side effects I seemed to be coping with, I knew I needed to be taking something as bad gastro issues.

After 6 months I had a really bad flare of my skin, which Dermy Consultant said was a drug induced systemic reaction to the Lanzoprazole.

You would think my skin was burnt/ scalded across a large area.

Dermo said they had seen this many times in patients with Lupus.

I now take H2 Blocker Famotidine instead.

Thankfully after 13 weeks of steroid creams and Dermy Appointments it's now cleared.

[panther50 in reply to Cardih]

That’s great news glad you got it cleared up. I went onto ranitidine eventually as I was going on IVF at time and that was safer. Then that was suddenly withdrawn after a cancer risk was identified in its processing. Amazingly I managed after 10 years to come off those too and now manage on gaviscon tablets alone. I had a terrible 2 weeks of rebound whilst doing it (wouldn’t have persevered if ranitidine had been available) but came out the other side and was ok. I think now my gastritis was part of the SLE inflammation.

[Cardih in reply to panther50]

Hi Panther50Sounds like it all turned good in the end for you I'm pleased to hear that.

Even though I informed gastro at Endoscopy I had Lupus and am receiving treatment, no one has mentioned a connection from gastro end , Like you I think there is a link to my Lupus and the gastro issues.

The rebound acid secretion was terrible for weeks as I needed to come off Lans immediately.

I relate to that.

We will see how I go longer term on the Famotidine fingers crossed

Thankyou for your reply

X

[panther50 in reply to Cardih]

Yes I was seeing an excellent rheumatologist at the time & her feeling then was that it was unrelated (stress). By the time the endoscopy came through it was months later, towards the end of the flare. They found gastritis but frustratingly they didn’t see it when I was in agony. It felt like I had ulcers, but I’ll never know. As the other symptoms went so did most of my stomach pain. My rheumatologist said with hindsight it did look like it had been part of the flare up. I don’t know if stomach involvement is rare. 🤷‍♀️Good luck with famotidine. I would never have come off ranitidine if it hadn’t been withdrawn from the market (drs never seem to try taking people off tablets unless there’s a medical reason) so worth being aware in the far future it could be possible if you wanted to try.

You’re welcome x

[Justshiv]

Hi Cardih

I was on lanzoprozol for 6 months when my skin broke out in a rash which over time covered most of my body except for my face. When I went to the dr they weren’t to sure eventually my dr took blood tests and referred me to rheumatologist and dermatologist. The dermatologist told me in rare cases some medication can cause skin lupus and one of them was lanzoprozol. I stopped taking the lanzoprozol and my skin over a little bit of time cleared. Unfortunately my bloods didn’t but I don’t have any other symptoms of lupus other than low platelets and positive ana. Hope this is useful

[Cardih in reply to Justshiv]

Hi Justshiv

Thanks for your reply.

Sounds like you went through a bad time too.

So stressful as the timescale for appointments to be seen especially during Covid, and the waiting, and during this time this thing is spreading further and further on your body.

I know exactly what you mean, glad you ok now

My whole back was taken over and it began moving elsewhere on my body.

So frightening until you get to root cause

I'm glad your Lupus symptoms not too bad at present

See my reply to Panther50

X

[Cardih]

Hi Troublesomelupus

Thanks for your reply much appreciated

I read the article

I'm sure PPI use is a medication that works well for some.

Sadly however this was not the case for me.

This is why I have posted the direct question on this site to see if others with Lupus have had a similar experience to mine.

It would be very interesting to know if this is the case.

I note the article claims PPIs are more effective than H2 Blockers well only time will tell, and I suppose individually we all may react differently

But i will share my experience on here with others for their information and also support if needed.

X

[panther50 in reply to Cardih]

Hi Cardih, I was looking something else up in my LUPUSUK Diagnosis and Treatment book and I notice that Lansoprazole is listed as a drug with a weak connection to drug-induced lupus as your dermatologist said. Thought you might be interested to know there was enough of a link for it to be listed (cimetidine which I’ve been prescribed & not taken yet also had a possible association). Don’t think GPs get this information, shame as your experience could have been avoided if they’d known.

[Cardih in reply to panther50]

Hi panther50

Thankyou for taking time to look for me its much appreciated.

I've been researching on various websites, into Lansoprazole use and found that it should be given with caution, to people who have Lupus.

I agree with what you say, if doctors had known more about Lupus it could of been avoided via alternative medication.

I do ask the question or rather pose the answer they should know more and gain an understanding before giving meds out.

To be honest the whole experience left me scared to take the meds that were put in place of Lansoprazole.

Hope I never go through that again.

Thanks for your reply x