Hello everyone. I just wanted to share some information with everyone that I learned the hard way. Methotrexate and high doses of Amoxicillin should not be taken together because the Amoxicillin can increase the side effects of the Methotrexate. My pharmacist should have alerted me to the interaction, but did not. You can look up online to see drug interactions and it shows a severe warning about taking the two together. I didn't know this until it was too late.
I had been taking methotrexate for about 2 months and my body was finally starting to adjust to it and my side effects were getting much better. However, I had to have 2 abscessed teeth (thank you Sjogren's) pulled. My dentist put me on 500mgs of Amoxicillin 4 times a day for 10 days before he could pull it.
Out of nowhere I got so weak that I couldn't walk without assistance (I'm 42) and if I didn't have help, I would collapse to the floor. Once on the floor, I could not get up on my own. I literally had to be pulled up off the floor and my husband would have to support my weight to guide me to the restroom. I felt like I was dying. I couldn't eat and had no desire to and could do nothing but stay in the bed. I went from 140 pounds to 133 in 5 days.
My husband took my methotrexate away from me like someone would confiscate an illegal drug they found in their partner's possession. He said the Methotrexate was killing me and he refused to let me take it anymore. In a couple of days I was better.
I just wanted to share this with the community because too often our doctors, dentists, and pharmacists give us medication that can interact with other meds we are taking, even though they have our chart of the meds we take and should know about the interactions.
My husband was quick to blame the Methotrexate, but it was the "innocent" Amoxicillin that caused the reaction when taken with the Methotrexate. I read and have learned that if a person takes Methotrexate and is prescribed Amoxicillin, they should skip their dose of Methotrexate until they finish their Amoxicillin to avoid a severe interaction.
I hope this helps someone and prevents the same thing from happening to someone else.
Have a good day everyone..
P.S. I eventually got my methotrexate back and have not experienced anymore problems while taking it.