I have Lupus/Fibro and been on methotrexate(Oral chemotheraphy drug) for a few years now but it has always interferred with my white blood cells. When the cells have dipped below what they should be leaving me open to infection my Rheumie Nurse has asked me to stop for several weeks before recommencing the drug. After several episodes like this I have decided to stop taking Methotrexate. The first month was agony but I have decided not to recommence the drug. I await advice from the Rheumatology Dept, but can anyone tell me in the meantime, if they have taken this decision and what the outcome was for them. I am a bit scared(its like loosing my security blanket) but believe this is the right decision for me. Thanks.