So I recently was diagnosed with Lupus. Although not all of my test results were positive for lupus, my doctor said he was going to go with his gut feelings and put me on 300mg of plaquenil to take daily. I have been taking it on and off. I'm also on Prednisone due to my platelets dropping to 22. So 40 mg of Prednisone and 300 mg of plaquenil daily. I believe I'm to take the hydrochloroquine every 12 hrs but I just am having trouble waking up for the 2nd dose ( ex. 6pm take 300 mg - 6am skipped that dose until 6pm again) I'm not sure what effects this is having on my body. I hope not killing myself. I haven't been eating the healthiest Because the steroids make me so hungry so I eat anything. I have very weird chest pain feels like alot of pressure. Abdominal pain and tiredness/ sluggish feeling after taking my meds. Is crushing them to powder harming me? Is the every 24 hrs not good either?