I seem to have an issue with Histones. I have always had an issue with my skin reacting quickly to any irritation, even applying moisturizer, by getting very red and then fading after about an hour. Having a cuddle with my husband always leaves me red and itchy on face and neck. Now I am getting hive like rashes or welts on legs and arms. They don't last long - and hour or two - but are obvious and not sure what is causing them. My Rheumi has mentioned several times that my histones are flaring when I have been at appointments. He says it rather casually and I mostly just let it go without asking him why. Last appointment he had a student with him and he was giving her my history and pushing her (as a teacher I guess) for her diagnosis, he mentioned a couple of times histones. I understand that histones make me red and are a reaction like an allergic one I think, how would this fit into a diagnosis? I don't see it as any one of the criteria for Lupus diagnosis - would it help get a diagnosis or be going in another direction. Thank you for any input on this.