I tested positive for lupus anticoagulant in the hexagonal phase after developing PE's in both lower lobes. I have all the classic symptoms and have had multiple DVT's. One doctor says I have hughes Syndrome and another doctor says that I don't because confirmatory tests are negative. I had an INR of 4 when confirmatory tests were done. So if I test positive but confirmatory tests are negative does that mean I don't have Hughes Syndrome and there is something else wrong? Does a confirmatory test always have to be positive?