Since Dr. Hughes is on the cutting edge of this disease, and since some of you have seen him, I am wondering if he routinely requests genetic testing after a diagnosis of APS is made.
I ask because there is something called an MTHFR mutation that can frequently be present in people with APS. I am not sure of the relationship between its presence and the presence of the antibodies themselves. HOWEVER, and this is a big HOWEVER, the MTHFR mutation can cause a whole host of problems. And based on the amount of anecdotes I am seeing here about fatigue and rashes and cognitive issues and balance, etc, I am wondering whether a lot of us with APS aren't suffering from the effects of the MTHFR mutation.
To quickly explain, MTHFR assists in the process of making B-vitamins bioavailable. If it is mutated, your body cannot utilize the B-vitamins you ingest. Therefore, simply taking a Folic Acid tablet isn't enough. You need the bioactive form.
Additionally, the mutation negatively impacts your body's ability to produce important antioxidants, such as Glutathione. Without these, your body cannot clean up byproducts of oxidative stress (free radicals) and also cannot chelate and excrete toxins we are exposed to environmentally, especially heavy metals.
Heavy metal toxicity does cause cognitive problems and aching joints and depression and a host of other problems.
Here are two videos that describe the biochemistry of what I have just explained.