Any one here with this particular ANA ?

[KellyInTexas]

I had just had a set of Rituximab 5 days prior, so my antibodies should have been really knocked down.

My anti cardiolipin was still a bit elevated at 26 I think. ( usually it’s down from 38 to 0. )

I actually don’t know anything about this antibody- I read the SS is Sjögren specific? Is that right? I’ve been on rituximab so long that I’ve not had the antibodies, just the symptoms, and am treating them. ( eye maintenance)

Is this a high count? Does it matter, or is it more just a positive or negative thing? Always thinking of the goal to lower inflammation in the body.

[Raw57]

I know nothing about this but I hope you get answers from the group and your doctors. You do not need another worry.

My APS labs remain low after my 5 month low dose Imuran treatment last year. I have not had any vasculitis like symptoms or vasculopathy symptoms in my legs either.

Best to you😊❤️

[KellyInTexas Administrator in reply to Raw57]

So glad to hear this- especially with the very high titers you had! ( great to hear from you)

[Star13]

Sjogrens is actually one of those where it’s difficult to get a positive result. Most people are very symptomatic but still don’t get a positive result.

pubmed.ncbi.nlm.nih.gov/208...

I would say that it means that the disease is reasonably active right now if those results come after your course. How Rituximab targets Sjogrens though I don’t know. Can Rituximab start to lose its affect if you have too many courses?

[KellyInTexas Administrator in reply to Star13]

Maybe, not sure. I do know many ladies in the infusion center have been taking it for a long time for severe RA and it continues to work. I take it more often than they do, though.

I know my rheumatologist told me I may start to develop antibodies against the rituximab.

Thanks for responding.