I am a 53 year old female who has tested positive to all 3 of the APS antibodies (very ¬high levels). Although I’ve never been pregnant or had any events I have been under the care of a rhemutologist for the last 10 years. My main symptoms had been fatigue, shoulder and neck pain, headaches and memory problems. The fatigue has been since I was a teenager so I don’t think it’s age related. Is it normal to come home from work and go to bed or sleep all weekend? I was put on 75mg of Aspirin 7 years ago and the change was remarkable – no headaches but the fatigue’s still there. Over the years they have also suspected Lupus (based on positive ANA and anti-dsDNA) however this diagnoses changes from highly likely to unlikely. My INR is 1 which I understand is normal for someone not on Warfarin but is this too low for someone with the 3 antibodies? Warfarin will not be prescribed unless I have an event but is Aspirin enough? Should I take Plaquenil to see if the fatigue/memory problems improve? I am based in Auckland, New Zealand and have private health insurance. Any help greatly appreciated.