I wonder if any one can give any advice/ information on the following.
Sorry if it is a bit long
My daughter age 32 has had various symptoms, over the years a tremor, leg jerks, pins and needles in arm, joint and muscle pain, cold feet and fingers, strange rashes, trigger finger, she has seen a Neuro consultant in 2014 who took bloods ( IgG igM lupus etc ) and MRI brain scan, bloods scan results were Ok, IgG 9.3. ( range 0-20) , he Just sees her yearly. However she has since been going through IVF and due to this not being successful she wanted immune bloods taken. Over this year the results of her IgG were June - 29.1, September - 58.9 (12 weeks apart), November - 9.01. She has now seen a haematologist who took further bloods tests with the November IgG, which included Compliment C 3 & 4, Monoclonal reporting IgG/igA/igM/. Imm ANCA 11F screen, Cytoplasmic ANCA, Pennuclear ANCA, ANA-hep 2, centromere antibody, dsDNA IgG, ESR, CRP, (not sure what they all mean ) all negative or within range, she has had a previous TSH which was in normal range (however not had T3/4 or antibodies) all general bloods in September were negative or within normal range including Vit D. However Protein S was low at 0.59 ( range 0.67-1.25) Folate was high at 20 (range 4.6 - 18.7 ) Haemogloblin 148 (110-147) Haematocrit 0.436 (0.32-0.43). She has been taking prenatal supplements which may be reason for high folate however she was concerned she may have MTHFR and not be processing the folate. Haematologist has given her another appointment in January she phoned him as she wanted to know if she needed any treatment and he said no, so she asked if she should see him January and he said "well you can come if you want". She feels a bit let down by all this . The question I want to ask is does she have APS with the 2 positive high readings ? What significance is the low Protein S ? Does she need any treatment at present or only if having IVF transfer or pregnant ? When the bloods were taken in November She was taking 75mg aspirin on fertility consultants advice as she had a IVF transfer which did not work, she has since stopped this. Hope this makes sense, Thank you.