I was diagnosed with APS after having a DVT and multiple PE's. Went to Mayo Clinic in Rochester, they told me my numbers were positive, but not high enough to be positive. So recommended I come off of the Lovenox and cont on baby Asa. I clotted again multiple PE's 5 months later was put on Xarelto, clotted on that twice. I've tested 3 times positive for APS had many clotting episodes and other symptoms and now my Dr.'s have me diagnosed with Hypercoagable State. My Rhuematologist just diagnosed me with Fibromyalgia and possibly the beginning stages of Lupus 3 positive ANA's in addition to other symptoms. I did request today to try Plaquenil to see if that would help. Won't know if I don't try. Just had surgery on my legs for venous insufficiency. Sunday's visit to ER revealed kidney stones which I've never had, painful oh my! Is all this related? I feel like I'm going crazy! Will the Plaquenil help? Thank you!