My nearly 50 year old husband has just been diagnosed with APS after 2 different bouts of multiple pulmonary emboli and various other unexplained health dramas going back over 30 years, including severe Sarcoidosis which claimed his spleen 4 years ago. Our son (late teens) has had IgA Deficiency since toddlerhood, and recently has suffered severe headaches and severe back/chest pains which could have been a PE although we had the hospital screen him for D-Dimer and it didn't seem to be PE. Our concern is that as both father and son have pre-existing Immuno disorders, and father has now tested positive for Lupus Anticoagulant, what is the likelihood of son having APS also? I know that it doesn't generally show up until later, and even if he test positive for markers there is no guarantee he'll develop disease, but I suspect it's possibly more likely. Anyone else out there who was IgA Deficient prior to diagnosis with APS? Anyone with experience of the interaction between severe Sarcoidosis and APS? Our GP is clueless (as seems to be the general experience). Any help gratefully received
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