Anticardiolipin AB, IGG blood test results?

[Hilariew930]

I recently mentioned I have been newly diagnosed. My most recent anticardiolipin igg test was at 111 and before that 109. My Dr. said that was a very high titer, but just how high are we talking about? Anyone know?

Thanks in advance.

Hilarie

[paddyandlin]

this is the base levels used for docs for referral

Negative: 14 GPL units/mL or less

Low positive or indeterminate : 15-20 GPL units/mL

Moderate positive: 21-80 GPL units/mL

High positive: More than 80 GPL units/mL

[Hidden]

Be warned that all labs have different ranges so it is impossible to compare results unless you are tested at the same place.

Hope the following helps:

Anticardiolipin antibodies – aCL

This is the main test for Hughes Syndrome. In simple terms, the chemical known as anticardiolipin is coated on a glass or plastic surface and the test serum is added. The stronger the binding of the blood serum, the higher the level of aCL.

Nationally, laboratories differ in the way they carry out their tests so it is impossible to compare results but, for an example, the ranges given out by St Thomas’ Hospital in London are:

aCL 0-15 - normal

aCL 15-40 - medium

aCL <40 - high

Many laboratories also record the particular class of the antibody (IgG or IgM) which is doing the binding, IgG being more likely (though not uniquely) to cause thrombosis. Again, laboratory ranges will differ all over the country but at St Thomas’ Hospital the ranges given out are:

IgG Range GPL

<2 Negative

2.0-20.0 Low Positive

20.0-80.0 Moderate

>80 High

IgM Range MPL

<3.2 Negative

3.2-6.0 Low Positive

6.0-50.0 Moderate

>50.0 High

The higher the titre (number) is, the more aPL a person has in their blood which suggests they are at greater risk of blood clots and other symptoms.

If a patient is already taking anticoagulants, including aspirin, heparin or warfarin, it is still possible to take the aCL test as the results will not be affected.

The aCL test is not perfect – possibly only 80% are positive in patients with Hughes Syndrome which is why it is also necessary to perform the other two tests – the LA and the anti-beta2GP1.

[Hilariew930]

Thank you. I've had all of those tests and have had high results on 3 separate occasions. Just curious if others had such high numbers also. This is helpful.