Histamine Intolerance Genetic Test Results - Healthy Eating

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Histamine Intolerance Genetic Test Results

dang profile image

Hi I’m not sure if I’m in the right place but hoping someone can help me. I have Histamine Intolerance and recently I did a genetic test to see if it’s primary or secondary.

Test came back positive on all 4 genes they tested, but I don’t really understand the results. Can anyone help? Or am I totally in the wrong community with this post?

Thanks!

11 Replies

Hi dang

I’m interested to hear that you’ve had a genetic test for for histamine intolerance. Have you had the other usual tests as well?

This is a general article on the subject. healthline.com/health/hista...

One poster called Little Toad has mentioned histamine problems, perhaps have a look for some of their posts?

dang profile image
dang in reply to Penel

Thanks for the info! I’ve had the DAO enzyme test 3 times, each time the result was <2 , so too low to even register on the scale.

Penel profile image
Penel in reply to dang

You need to make quite sure that there are no other possible causes for your health problem. If you were already on a low histamine diet, this could give you a very low reading. Unfortunately I can’t speak German, so have no idea what your results say.

histamineintolerance.org.uk...

dang profile image
dang in reply to Penel

The test isn’t for Histamine levels, although I have been tested for that too. The test is for the enzyme DAO (diamine oxidase) which removes histamine from the body, if someone is deficient in this enzyme they can’t efficiently digest histamine. So the result is unrelated to how much histamine is present in the diet. Every test I’ve done shows that I’m completely deficient in this enzyme. I’ve also had results come back with low Histamine levels in the blood which shows that my low histamine diet is working (against one doctor’s wishes I stopped taking antihistamines and focused on eating an incredibly restrictive diet super low in histamine, and I’ve been reasonably successful).

Now this genetic test supposedly shows that I have 4 gene variants that would explain it (in german it says i tests positive for all 4 variants therefor giving me a diagnosis of primary histamine Intolerance due to genetics). But I don’t know what the “normal” reading would be, and I can’t find this info online 😓 it’s been frustrating. The numbers (genetic codes) would be the same in English so I’m really hoping someone on this forum knows how to read this stuff, and can explain to me simply what it means that I have those 4 variants, if it’s hereditary, does having all 4 variants guarantee histamine Intolerance? Etc... basically I’m looking for a geneticist 😅

I would definitely love to know if this is related in some way to my other health conditions but no doctor has been able to say, and I’ve hit the end of what’s researchable online on the subject, there isn’t really so much known yet about histamine Intolerance.

Penel profile image
Penel in reply to dang

It certainly seems to be a complicated problem. At the risk of internet overload, this article seems to have a lot of information, although I don’t know if it’s relevant.

academic.oup.com/ajcn/artic...

Good luck with finding some answers.

dang profile image
dang in reply to Penel

Yea it unfortunately is 😓 but thanks for your help and the info you’ve shared it’s much appreciated! 🙂

Useful if you could post the "results" to see which tests were done and the results. :)

dang profile image
dang in reply to

I just added the results to the post! I also had DAO enzyme tested multiple times but that was separate, each time result was <2.0

Perhaps take a look at healinghistamine.com/the-hi...

Also bohemianvegankitchen.com/lo... is a vegan story of dealing with this issue.

dang profile image
dang in reply to andyswarbs

Thanks I checked it out unfortunately they don’t mention the genetics of it.

dang profile image
dang in reply to andyswarbs

Thanks I’m actually dealing with the issue with my diet quite well. My post is about the genetics, and specifically the 4 genes outlined in my post. I’m trying to find someone who can read a genetic test.

But thanks for the info it’s always useful to read more on the diet :)

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