Changing from pBAT 1 month cycle to cBAT 3 month cycle

[KocoPr]

Here is my pBAT Highs and Low PSA for the last 15 months. use CTRL+ to zoom image

My pBAT cycle is starting to cause my PSA to rise slightly (Not a bad thing), (see picture)

but I want to try the cBAT (cypionate BAT) for a few reasons.

1:Longer T time from 2 weeks on pBAT to 2 months on cBAT. Of course that will also increase my low T time from 2 weeks to 1 month.

2: The clearance of darolutamide on pBAT requires one week of no treatment thus cutting into high T time where as on cBAT i can stop darolutamide one week before High T while still on Orgovyx and then just jump right into High T.

Here is my test scenario. (Mateo Beach Please advise on this schedule)

30 days of Daro and Orgo - 1 week off of Daro on every low T cycle.

Next day Day 31 or I will call it Day "0" of High T start. so

Day 0, 14, 28, of 400mg T-Cypionate, Day 42,44,46,48,50,52,54,56,58 T-propionate75mg.

Day 59 let T=prop clear then Day 60 30 days of low T cycle.

[cujoe]

KocoPr - Sincere thanks for the share of your BAT results. I'm not on BAT, but see it as a future treatment option. You and the others who are sharing their experience provide invaluable info for those that may one day follow your lead.

I trust you will get feedback from mateobeach. Also, Patrick probably still reads here even though he cannot reply or comm via chat. I do comm with him via email and can relay a comment if he provides one to me.* I seem to remember that he does not target "undetectable" PSA, but rather something in a low single digit range.

Best of luck tweaking the cycle and the use of cypionate. Stay S&W,

Ciao - cujoe

* * *

* Note to HU Admins: Why not end the ridiculous (and unjustified) restriction on Patrick's ability to share his diverse knowledge and personal experience directly to help PCa patients LIVE LONGER!!!! After all, this is what HU says is its purpose:

"Empowering self-care"

"Imagine a world where everyone can share their experiences of healthcare, free from stigma or judgment. Where you can talk to people living with similar medical conditions, and gain support from caregivers and patient organizations - whilst also improving your health outcomes."

"That's what HealthUnlocked from PPD, part of Thermo Fisher Scientific does. We provide the information, support and expert-curated resources to change lives. We're also a research tool for clinical development, helping pharmaceutical companies put the most important voices at the heart of research: people."

[Jac_J in reply to cujoe]

Patrick is restricted because he does not preach what the medical profession generally does (SOC).

I am very open minded in terms of treatment options but this site is all about pro pharmaceuticals and recognised treatments by the Medical professionals.

Drink the cool aid or move on.

[KocoPr in reply to Jac_J]

The best you can do is USE the system to YOUR advantage. The power of 20,000 fellow warriors is powerful! Powerful pharma, powerful drugs, powerful diagnostics, and all of it powered by researchers and all of it accessible if you want it. You have to work with the system and take advantage of it.

[podsart]

your bio shows Gleason of 3 + 3, theoretically a more benign Pca than most on this site , I believe. Regardless, I applaud your comprehensive approach, Ala Patrick.

Looking at your graph, seems your trend line has shifted materially up and your peak to trough dramatically increased. You mention increased psa a good thing: why? Do you have a handle on what has created this material change in your graph’s [psa] performance?

do you find that Orgovyx plays well with Dara? Any side effects, especially from Orgovyx?

I assume you are self injecting and your doc is giving you full support: may I ask who your onc is?

[cujoe in reply to podsart]

podsart - With all due respect, you need to more carefully read KocoPr's treatment profile; i.e.:

- 05/21/2015 RP/LND. Path: Gleason 3+4 adenocarcinoma. Positive ECE. (Extra Capsular Extension). Positive PRI, Perineural Invasion. Negative SVI. Negative LNs. Positive margins bilaterally. Post operative PSA 0.1.

- 09/2015 - 10/22/2015: Salvage EBRT to the prostate bed.

[podsart in reply to cujoe]

thanks

[cujoe in reply to podsart]

You're very welcome. Also, I think KocoPr made a mistake in his reply to your question about the Gleason of his initial needle biopsy, as his profile states that was 3+3 in 2 of 12 cores. His biopsy was done circa the last needle biopsy prior to my own RALP in fall of 2013. His was also TRUS-guided, so less accurate targeting than current MRI-guided biopsy. He did not indicated any change in Gleason with final biospy results, but, as was common at that time, mine flipped from a pre-RALP 3+4 to 4+3 with the final biopsy.

[KocoPr in reply to podsart]

Hi Podsart, my initial needle biopsy was 3+4 but my prostatectomy biopsy upgraded to 3+4 with perinueral invasion. I also have somatic TMPRSS2/ERG fusion and IHC MSH6- Loss. Darolutamide does a great job of blocking the ERG fusion

ncbi.nlm.nih.gov/pmc/articl...

Darolutamide antagonizes androgen signaling by blocking enhancer and super‐enhancer activation

As far as Orgo goes it plays excellent with daro. I don’t do Orgo continuously.

[podsart]

thanks for info

[MateoBeach]

I like it very much KocoPr. Two months of maintaining supra physiologic T with 400 T-cyp every two weeks and the last weeks using T-prop to let the cypionate clear. That’s what I do. Five weeks after the last T-cyp shot should have it well cleared. Darolutamide with the Orgovyx for the first weeks will block any residual. I do 2 weeks with the darolutamide and the last two just Orgovyx, just to conserve my supply. We will just have to see how it works for you and be ready to modify or abandon if necessary. Get as much time out of it as you can. O expect all treatments eventually fail. Best of luck. Paul

[KocoPr in reply to MateoBeach]

Yes, flexibility and knowledge to delay the inevitable is the key!

Thanks Paul