Developments in the nanoparticle world and how to determine and predict chemo benefits in MHSPC

[NPfisherman]

Hello FPC members,

The nanoparticle developments keep coming and there have been quite a few in the last several weeks.. Breakthroughs in directing nanoparticles to tumors and visualizing they arrived by targeting the antigen EGFR...

sciencedaily.com/releases/2...

One of the problems for the immune system is that cancer cells "cloak" themselves to prevent the immune system from attacking and destroying tumors... John Hopkins develops a method using nanoparticles to "uncloak" cancer cells to present them for attack to the immune system...

sciencedaily.com/releases/2...

Scientists have looked for a way to attack drug resistant bacteria and cancers..The development of microscopic sized "nanodrills" to punch a hole in resistant bacteria and tumors...

sciencedaily.com/releases/2...

and lastly, a way to determine which patients with MHSPC will benefit most from chemotherapy...

prnewswire.com/news-release...

The Science is Coming !!! and it gives us....HOPE !!!

Don Pescado

[6357axbz]

Hey Don, thanks for keeping us up to date on these little nano-blasters! How long would you guestimate it will be before first trial?

[NPfisherman in reply to 6357axbz]

Nanotechnology has gone from science fiction mode to reality relatively quickly...If you recall, I had this article in a post regarding the Autolase treatment which is already in clinical trials... see below:

sciencedaily.com/releases/2...

The beauty of nanoparticles is that these are a medical device and not a medication and so they should be able to get through clinical trials faster...generally devices take a few years where medications take longer due to concerns of drug to drug interactions, side effects, etc... We have Sir Spheres........ SIR-Spheres Y-90 resin microspheres are microscopic resin beads that contain the radioactive isotope Yttrium-90 (Y-90) and emit radiation to kill cancer cells.

My best guess is that within 3-5 years, we shall begin seeing some more nanoparticle treatments in testing or use...here's hoping..

Don Pescado

[cujoe]

Mr. Wizard,

Good post. I saw the individual articles at ScienceDaily, but you pulled them together into a solidly informative post.

Also, the Decipher update shows how genetic testing companies are improving their products and tailoring them to the PCa patient population. Good news for all of us.

Be Well - Captain K9

[NPfisherman in reply to cujoe]

K9 Terror,

I think it helps to group these breakthroughs together into distinct categories like nanoparticles, or immunotherapy, etc and by putting several articles together it can show forum members how these might be combined in a way to benefit them....for example, could the nanodrills be released to punch holes into tumors/ cancer cells, and then release a EGFR targeted attack, followed up by an uncloaking of the tumor/cancer cells for immune system attack/ clean up.?? Maybe... By combining articles, it also allows forum members to save less posts packed with more information in areas of interest to them...

The thing to realize is that there are breakthroughs in Science coming and there is real hope....We have come farther in less than 10 years than we did in the prior 90 years... Abiraterone was approved in 2011... Now, we have enzalutamide, apalutamide, daralutamide, radiopharmaceuticals, and several drugs headed into Phase 3 testing that are newer classes of drugs.. We are seeing crossovers--drugs used for small cell lung cancer being used against neuroendocrine PCa... The PARP inhibitors were initially intended for Breast Ca and now they are here...

My goal is to serve up information and hope... As Andy wrote to Redd....

youtube.com/watch?v=9K30e9O...(Not working as expected?)

I am hoping this post finds you well, my friend... be seeing you again, God willing...

Fish

[Hidden]

Nano nano Don Pescado !

[NPfisherman in reply to Hidden]

Are you from another planet, Mork-Whimpy-P?? Or perhaps just on an intergalactic voyage.... Travel safe....

Fish

[Hidden in reply to NPfisherman]

Hopefully all of the above! 🪐

[Fanger1]

Thank you for the information post😺