Doctors in Perth, Australia are leading a Phase 3 clinical trial called ProstACT GLOBAL, which is investigating a new radiopharmaceutical treatment for advanced prostate cancer. The trial is sponsored by Telix Pharmaceuticals and is being conducted at GenesisCare’s Theranostics facility at St John of God Murdoch Hospital. The treatment uses a radio antibody-drug conjugate (rADC) that targets the prostate-specific membrane antigen (PSMA) found on prostate cancer cells. This allows the treatment to deliver radiation therapy directly to tumor cells, minimizing damage to healthy tissues.
The ProstACT GLOBAL trial is a multinational, multicenter, randomized, controlled study that will evaluate the efficacy, safety, and quality of life benefits of this new rADC treatment for patients with advanced, progressive metastatic prostate cancer who have not responded to other therapies. The study will also examine the drug's pharmacokinetics, biodistribution, and radiation dosimetry. The trial builds on previous Phase 1 and 2 studies that have shown promising results in terms of safety and potential improvements in survival and quality of life for prostate cancer patients.
I don’t even have a community, just a repository of research articles, what difference does it make if the link is to my blog or to another source? I add a link to the original source or trial anyway
You have been banned?? Say it isn't so !!! Another banishment.... such news....shocking !!! When individual voices that look to the future are silenced will it result in a kinder, happier forum, or rather an environment that results in cancer patients having fear about sharing knowledge in writing lest their existence be eliminated...
If you are banished, then welcome to the resistance ...
Well, I could have avoided that...but I really felt I was being exploited...same person that banned me had a videochat with me like 6 months ago to have me writing articles for some new site they planned to launch....
Sometimes you get the carrot, and sometimes the stick... after all, you are just a cancer patient on a cancer forum... well.... things can happen... exploited !! shocking !!
I take it you had a run in with one particular poster who believes that only he knows the science... Despite being a Nurse Practitioner, I found that my input was not valued as well...
No no, you will find the explanation here in a post I have written to explain. I was banned because of self promotion, and because I have solicited donations for a Gibson Les Paul 😃
TLX591 is Telix’s renaming of J591. Same thing. A human monoclonal antibody to PSMA to deliver 177Lu in a better way do to strong and persistent binding. It is not excreted in the urine so there is no no renal toxicity. But the persistence in the circulation increases marrow toxicity, especially if many bone mets present.
This is the same treatment I had in Perth at that facility. As mHSPC I did not meet criteria for the trial. But it was available to me out of pocket less than $3000 US for the one treatment that was split into two infusions. Worked extremely well for me as I remain PSMA undetectable early 3 years later. I remain on BAT with PSMA <.015 on high testosterone and .020 when on Orgovyx and Nubeqa. Side effects were mild for me and over in one week. I do not need a second cycle of this treatment so far. Much better than Pluvicto IMO. Paul MB
that’s a great result. I have spoken to them about radiotherapy as well but hadn’t done anything. I’m doing BAT at present with zoladex. My psa is climbing a bit from 2.1 to 2.8 last test so looking at what next. Might look at this before abiraterone. I am advanced stage 4 diagnosed June 21 with extensive bone Mets and have had chemotherapy in 2021 as well. I think have only a couple of Mets at the moment so may work for me. Any thoughts?
If you can get SBRT to the few Mets that are visible on PSMA PET scan then follow it a month later with the Lu-TLX591 at GenesisCare in Perth. That is what I did as it is particularly good for going after remaining micro mets and even circulating cancer cells. You can get a virtual consult with Dr Nat Lenzo who manages this program and the trial. Great guy.
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Seminal Vesicle Invasion & Senescent tumor cells.