Individual cancer models for tx success, Nanoprobes detect cancer more precisely, new organelle in bone mets discovered, off-the-shelf tx

[NPfisherman]

FPC members,

Some more new science to engage your minds. First, producing an individualized organoid to test treatments against and to predict treatment success in prostate cancer. Personalized medicine/ Targeted therapy is coming:

sciencedaily.com/releases/2...

Second, new nanoprobes detect cancer more precisely than previously and can be used to identify treatment sites:

sciencedaily.com/releases/2...

Third, new organelle discovered that plays a significant role in bone metastasis in breast and prostate cancers. The role of the gene DACT1 in allowing metastasis to happen.

sciencedaily.com/releases/2...

Lastly, the future of immunotherapy in off-the-shelf treatments. The development of neoantigen therapies that could be removed from a shelf and given to engage the immune system. The post I wrote on Advaxis discussed their new vaccine program using multiple neoantigens to achieve a significant immune response against prostate cancer. From the article:

Weidanz said immunotherapy holds the promise of transforming cancer into a more manageable condition with better prognoses for patients.

"We are getting to a point where we will be able to make cancer more of a chronic disease," Weidanz said. "Now, we look at five-year survival. Maybe we can start looking at 15- or 20-year survival readouts because we're able to manage the disease with immunotherapies that are being developed. It's a very exciting time."

sciencedaily.com/releases/2...

Keeping an eye on the science....

Don Pescado

[Bodysculpture]

Thank you Fisherman very encouraging

[NPfisherman in reply to Bodysculpture]

It is encouraging...the concept that science can take your prostate cancer, develop a model to test treatments to decide what works best and use it; prevents the lost time of treatment failures and will add time to patient's lives. Better detection and a new target for bone metastasis and the good news that cancer may become a chronic disease. All good stuff. Too many die at too young of an age within 5 years. The survival rate has improved some, but a lot more is coming.... Thanks for the reply...

Fish

[jdm3]

Thanks Fish. Encouraging because we have a brother keeping a close eye on the science.....and because the science is encouraging. The question I have is when and how will this be accessible to people who want or need it? Right now it seems mostly academic and I wonder at what point it becomes part of the oncologists' SOC.

[NPfisherman in reply to jdm3]

I would guess (no one can predict government approval) that on the nanoprobes and organoid for individualized treatment testing--3 to 4 years based on the info below:

qualio.com/blog/fda-medical...

The newly found target for bony metastasis and finding a treatment will take the usual 10 years, but the "off-the-shelf" neoantigen vaccine is entering Phase 1 at Advaxis. The other "off-the-shelf" vaccine candidate in their program had good interim data on blocking disease progression (believe it was lung cancer) and safety. . I am watching to see if I qualify...

Fish

[jdm3 in reply to NPfisherman]

Hopefully some of the momentum and research from getting COVID vaccines in unprecedented record time (!) will help accelerate other research and solutions for many diseases, including PCa. 🙏🤞

[NPfisherman in reply to jdm3]

I think we will see an mRNA vaccine for PCa coming from CoVid research. While a cure is what everyone wants, adding an extra 5 years is great too. I think we will see PCa become more of a chronic disease as the researcher in one article stated and in our lifetimes. For the sad cases caught so very late with massive number of metastases, a vaccine may not buy years....Sadly !!!

Fish

[TheTopBanana]

Thank you!! I can’t express too often how much I appriciate you taking the time to break down science news here on the forum.

[NPfisherman in reply to TheTopBanana]

You are most welcome... The Science is Amazing and the developments over the last 10 years have been incredible...When one considers that until 2011, there was just Lupron and now....much more with much more coming... There is hope....

Fish