About a year ago, I posted a series of articles on prostate cancer vaccine candidates, what I felt was their potential, and relevant information from clinical data. I thought it might be time to give an update and see what has happened in 1 year.
Let's begin with RV001, which I felt has great potential for PCa sufferers. This was my post from last year:
Rhovac has now completed Phase IIb, and the study will evaluate this treatment in more than 175 patients and is aimed to release data by the start of 2022. The company has submitted data to the FDA resulting in a fast track designation for the drug, which will speed up review and approval.
Next, I posted on Advaxis, a company with 2 PCa vaccine candidates-- ADXS-PSA and ADXS-504 ( a neoantigen vaccine-off the shelf).:
At this point, ADXS-PSA has not yet announced Phase III trial despite positive phase II results. There is an announcement of the initial Phase I trial for ADXS-504 as below:
Thanks for the update. Need to hold on and hope the science arrives. Will be interesting to see the Rhovac phase 11b results in early 22. I wonder why Advaxis have not pushed on to Phase 3 perhaps they need to raise money?
Thanks for the reply. I am also wondering the hold up on Advaxis, but they have a number of projects going. There may be the matter of finding a partner for Phase 3, but they may be working out a deal with Merck since Keytruda was involved.
I am REALLY WATCHING RV001 because of the 86% response rate for immune response (CD4 T cell response) and the fact that it is targeted for metastases. What killls cancer patients?? Not the primary, but metastatic lesions spreading. Stop metastasis and a chance for a cure goes up dramatically, or certainly, prolongation of life...
Fish. Thanks for the extra information. I do think a vaccine will ultimately end up being at least very helpful. About 3 years ago I attended a talk in UK by Helen McCarthy from Belfast who is working on one. Hope you and yours have a great holiday season too.
I think a vaccine will be crucial early on in stimulating an immune response to hold Pca in check while additional treatments are given...buying time and stopping disease progression...
Fish, thanks for this. Yes from what I remember from the talk, which was extremely technical and a lot of it went over my head (Lol), a lot of it was about the efficacy of the vaccine delivery mechanism as well as the vaccine itself. It seemed very clever stuff but this seemed to be in very early development and some years away. I do support Prostate Cancer UKs research projects. You have an encyclopaedic knowledge of all this stuff I am well impressed that you have managed to unearth this as well. Fully agree it’s all about buying time which is the most precious commodity we have got.
Being involved in healthcare has helped in assimilation of Pca knowledge. Thanks for your support of Prostate Cancer UK. On my side of the ocean, I give generously to Prostate Cancer Foundation (PCF) and over 80% of donations go to research towards a cure. Buying time is everything.
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Nitric Oxide -- slows prostate cancer progression and PSA doubling time.
Modified Citrus Pectin
Genistein potentiates the radiation effect on prostate carcinoma cells
