MedPage Today: Decipher Test May Guide Post-Surgical Tx in Prostate Cancer - — Another step toward personalized therapy? February 11, 2021

[cujoe]

From the article:

"Scores with the 22-gene Decipher genomic classifier (GC) were independently associated with risk for metastasis, prostate cancer-specific mortality, and overall survival among men with recurrent prostate cancer treated with salvage radiotherapy with or without bicalutamide."

"These results suggest that not all men with biochemically recurrent disease after surgery will benefit from hormone therapy, reported Felix Y. Feng, MD, of the University of California San Francisco, and colleagues in JAMA Oncology." (emphasis added.)

Article is here:

medpagetoday.com/hematology...

And for those with a JAMA account, an accompanying editorial by Sean E. McGuire, MD, PhD, of the University of Texas MD Anderson Cancer Center in Houston, is here:

jamanetwork.com/journals/ja...

Required reading, as Decipher may be a critical new tool in making effective treatment decisions.

Stay Well - K9

[NPfisherman]

K9 Holy Terror or are you Unholy?? (grin),

By revising the test and adding the genomic classifier, they have increased the relevance for the test as well as improving treatment decisions. As PCa patients, knowing the SE of hormone therapy, we can see the benefit of knowing whether hormones therapy is needed. The Science continues to evolve....better testing....better treatments.... chances to take breaks from treatments, remissions.... improved decision making and QOL for PCa patients....nice find.... Thanks for posting...

Fish

[cujoe in reply to NPfisherman]

Thanx for the compliment. (I think?)

As one who has been off ADT for 3+ years, anything that would help select for effectiveness and allow others to never go on ADT or have extended vacations would be a QOL boost that anyone who has even been on it can appreciate.

It's your science at work, Amigo.

[NPfisherman in reply to cujoe]

A compliment indeed... I will sit down and read your other post in a bit....Out shopping and getting ready for the big snow storm...Winter needs to be over soon... Mother of Pearl, I have done enough shoveling... Yes, the vacations are a blessing... our friend is at the 2 year mark for his vacation and hope he has many more...... I am watching for the ORIOLE trial updates and early results of the RAVENS trial... Life is Good and The Science is Coming !! Two of my favorite sayings...

Be safe and stay warm...

[cujoe in reply to NPfisherman]

I'll take the cold rain here over the frozen forms you "Northerners" are dealing with this winter. And while we are both hanging near the heater inside, Nal is waist-deep in water catching fish in Florida. Medical vacations and physical ones both have verifiable benefits.

You and Lady M continue to Stay Safe! Some science is here, but more is coming.

K9

[NPfisherman in reply to cujoe]

Yes, cold rains over snows any day. .. My electric snow blower shovel went up in smoke literally. (Not like Cheech and Chong), so I got an improved model, but heavy snows next week. CoVid plus winter weather sucks HUGELY !!...

Stay warm...

Fish

[cujoe in reply to NPfisherman]

Maybe this will help ease the pain, Dude

youtube.com/watch?v=Alyx4Qe...(Not working as expected?)

[NPfisherman in reply to cujoe]

Well K9,

If I had a doobie that big, it would take me a long time to smoke it... the newer weed is so much stronger than what I used to buy in college... been a while since I got my party on....LOL...

Fish