A very long way from human application, but a possible major advance in CAR-T that would make it available to many more patients - and in lab tests it works on PCa. From the BBC Article:
What have they found?
Our immune system is our body's natural defence against infection, but it also attacks cancerous cells. The scientists were looking for "unconventional" and previously undiscovered ways the immune system naturally attacks tumours. What they found was a T-cell inside people's blood. This is an immune cell that can scan the body to assess whether there is a threat that needs to be eliminated. The difference is this one could attack a wide range of cancers. "There's a chance here to treat every patient," researcher Prof Andrew Sewell told the BBC. He added: "Previously nobody believed this could be possible."It raises the prospect of a 'one-size-fits-all' cancer treatment, a single type of T-cell that could be capable of destroying many different types of cancers across the population."
This is more of the fabulous science that is coming...Great find and thanks for replying...This falls in there with the new Advaxis HOT program---ADXS-504, -that vaccine has 30+ antigens appropriate for prostate cancer and if someone has PCa, then you pull this off the shelf and inject IM...
Having been in the first generation to be vacinated as children for polio, I like the sound of and the broad suitablity of a PCa vaccine. May we some day look back at PCa in the same way we do today on polio. Thanks for the info. Be Well - K9
I think the immunity focus is taking us where we need to go...the idea of first, amping up immunity with the idea of doubling or tripling PSADT to begin with and then looking at something like SBRT for mets <10 , and then seeing where the patient is at... granted that there will be people that have large amount of mets and should likely start with docetaxel first, but holding off on ADT ....slowing the process to MCRPC.... seems to make sense to me... of course, this is all IMHO....
As the Science develops, the protocols will change.... Things are getting better, but it takes time.... I think my sons will never have this worry as my oldest is 29 and I got this at 59, ....we shall see... I have him on the right trail lifestyle wise...
These are 100% appropriate ...some of what we have put out today about VISTA involvement, and how to enhance the usage of immunotherapy ...Thank you for replying with these links....The Science is Coming !!!
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