Hi! 🤗

Hi my names Jacquie. Pleased to join you. Hope everyone's not feeling too bad today!

I was wondering if anyone who's taken/taking Pregablin for CFS and fibromyalgia would share there experience with me? How did you get on with it?

It's just that I have found my depression and anxiety has worsened and the pain is only slightly better. So I asked my doctor if he thought it was to do with the Pregablin but he told me that Pregablin helps with depression and anxiety not make it worse! So I don't know what to think now.

Can anyone help please?

Thanks in advance


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23 Replies

  • Hello Jacquie welcome to the site. Hope to hear a lot more from you

  • Hi Maisie thank you for your kind message. I've just edited my first post and included a question would you mind having a quick look and sharing your views with me?X

  • I have pregabelin for anxiety. I haven't got fybromyalgia but I do get pain in my leg. I find amitriptyline a good all rounder

  • Ok so Pregablin helps with your anxiety then... Interesting. Thank you! X

  • Hi welcome to this site - I take pregabalin for pain in my legs, hips, etc it helps but couldn't cope with the 6 tablets a day the doctor prescribed so she has put me on two a day - she said it may also help me sleep better - but as you can see it doesn't !!! 😩. Neese x

  • Ah bless you Neese. I take Amitriptyline they normally help me sleep at night but on the odd occasion I still feel to wired to sleep. A natural aid is melatonin if that helps at all.

    God bless X

  • Ok thank you - sleep is a bit of a problem for me 😩x

  • I asked my GP about melatonin and she told me she can give a higher dose to children with ADHD but if I wanted to have the same dose it would be through a consultant. I think amitriptyline is one of the better sleeping aids

  • I take pregabalin for fb and the only side effect I've had is rapid weight gain which they don't tell about but I've still got pain my medication has only to the edge off it and I am also on morphine twice a day hope you sort things out and welcome to this site which is friendly and helpful Carol ☺

  • Hi Jacquie

    Welcome 😊 It's wonderful to have you aboard.

    If you have a look at our mother site you'll find lots of information on Fibromyalgia fmauk.org

    I started Pregabalin about March time this year. I found that it helped enormously with my anxiety, only helped very slightly with my pain, but oh goodness me, my depression got very seriously bad.

    I hadn't linked the two together until I remembered one of our members warning someone to keep an eye on their mood with this med.

    The thing with us Fibromites is that we all react very differently to medications. Doctors tell us what is printed in their doctors bibles (the name escapes me at the moment) and as far as most doctors are concerned nothing different can happen.

    So.... from my own personal experience Pregabalin has made me more depressed for sure.

    I just wanted to say whatever you do don't just suddenly stop taking them though. If you want to come off any medication you need to do it very slowly with the help of your GP.

    If you don't wean yourself off medications you can end up getting some very serious side effects.

    I hope some of this helps.

    Wishing you less pain and more peace

    Lu x


  • Thank you so very much for your message Lu. It has really made me feel better about it all. Started to think I must be an alien of some kind if it helps everyone else with depression just not me. It's nice to hear I'm not 😊

    Big but fragile hugs



  • Hi Jacquie

    I'm so glad you're feeling better about yourself.

    Just promise me that you wont just stop taking them. It honestly could make you extremely ill.

    You need to wean off them properly.

    Many thanks for the big but fragile hugs. They were much needed and right back at ya ☺ xx

  • Thank you. No I won't just stop taking them I promise. Thanks for caring 😊X

  • Hi and welcome to a great site!! I font taken or gave I ever taken this med but I know some on here do so you will get an answer. Chat later.Peck🐤

  • Welcome to the forum. Sorry to hear that the Pregablin has had little effect apart from appearing to lower your mood.

    From the patient leaflet 1 in 100 people experience:-

    • Change in perception of self, restlessness, depression, agitation, mood swings, difficulty finding

    words, hallucinations, abnormal dreams, panic attacks, apathy, aggression, elevated mood,

    mental impairment,

    As Sorebones says don't just stop it but if your body is not adjusting to the tablets as some of the side effects are temporary you do need to talk to you. Gp again. Good luck with it all.x

  • Thank you so much. That's teally helpful info X

  • Hi Jax1977

    Welcome to the forum and it is wonderful to make your acquaintance. I take Pregabalin but mine is used as a Migraine suppressant. It may help to discuss how you are feeling and your thoughts about it with your doctor?

    I want to sincerely wish you all the best of luck, and please take care of yourself.

    All my hopes and dreams for you


  • Thank you so much Ken

  • :)

  • I'm relatively new to pregabalin, it's only my second month or so on it. At first I saw a big improvement in my pain level but this quickly passed and I would say the improvement in pain level on this drug is negligible. On the other hand I do feel it has improved my general mental health. Before starting the tablets I had gone from a patch of crying at the slightest thing but do generally feel more happy since the tablets were prescribed. Maybe part of my improved happiness can be attributed to my most recent hospital visit where I felt things were being dealt with more seriously, I don't know. I'll keep taking the tablets unless I feel they are starting to impact on me negatively.

  • Hello Jacqueline

    I've taken Pregablin for a few years now and the dosage increased. It does help me function. I also take Setraline for depression, and morphine for bad pain I can only take 2.5ml at a time as it make me ill so I do try to avoid morphine if I can.

    It took me a while to notice a difference in myself and my husband noticed to, so in my opinion no harm in trying and as I said the dosage can be increased 25mg a time.

    I wish you well, and let me no how your doing.


  • Thank you Siv, I really appreciate that. Hope you're having a good day

  • Thank you Siv. All of what you've said is a mirror imagine of me (minus the morphine) until you said it had helped your mood. It seems to have had the exact opposite affect on me. My depression and anxiety has got a lot worse but when I told my Dr he just laughed and said no Pregablin helps with that! I just broke down into tears and then he promptly highered my dosage. I don't know what to do now. Xxx

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