Double embryo transfer (3AA & 5AB) - experience and advice?

[VeeVee_bb]

Hi all - I did a double transfer back in April period (4AA & 4BB). I got a positive on day 6 but sadly, the HCG never increased quick enough so I lost it in week 5.

I have 2 embryos left with this clinic (3AA & 5AB) and am trying to decide what to do. My embryos weren't tested so out of these 2, I'd be lucky if 1 of them is normal. I just assumed the 2 transferred in April were aneuploids..

I know the clinic will advise me to transfer the 3AA first; I'm just wondering if I should opt for a double transfer again. Will the lesser grade affect the better one?

Would welcome any advice/views and experiences to help me decide!

Thanks all.

[VeeVee_bb]

Forgot to add, I'm 42..

[Twiglet2]

I would transfer them separately and take clinics advice on what one to do first. I’ve did quite a lot of double transfers that have mostly all ended in chemicals, my consultant told me about some emerging research where one of the ‘poorer’ embryos can affect the implantation of a normal one especially if they are of different grades. We decided to move to single transfer even though we had 2 embryos last time (both 4ABs) the first didn’t take at all but the 2nd one I’m 26 weeks pregnant with. I dont know if this helped but I had 9 transfers before this one and I’m glad I gave this one a chance on its own so I would know for sure no effects from the other one . There is really no right or wrong answer though and all my other ones could have been destined for chemicals anyways (I’m also 42) whether I had done double or single but it gave me peace of mind to know we had tried this way after trying the other of that makes sense? Good luck! Xx

[VeeVee_bb in reply to Twiglet2]

Thanks for responding and sharing your story, and congrats! Wishing you a smooth pregnancy.

I am leaning towards a single transfer (I think). I think it makes sense considering one is better than the other.

[Twiglet2 in reply to VeeVee_bb]

I was totally all for double transfers and did quite a few of them for the sake of time and money etc so there is defo no right or wrong answer! Just the last few I changed tactic even though my clinic were happy either way. The same thing happened in 2020 with my son had a double transfer and had a chemical, next transfer I was told had to be a single transfer during covid and resulted in my son so I am probs just a bit biased now xx

[Doodlebug23]

I did a double transfer of 5 day AB and 6 day BB resulting in a single pregnancy.

[VeeVee_bb in reply to Doodlebug23]

Thanks for replying and congrats on your pregnancy!

[Spicycurry]

There are not too different in grades. 5AB is very good. I think it depends on age with transferring two. I’ve tended to do double transfers from the age of 38.

[VeeVee_bb in reply to Spicycurry]

I am 42 so yah. I'll see what the clinic advise this time..

[Spicycurry in reply to VeeVee_bb]

The only thing that affected implantation rate was when my lining was thicker. When I had a thinner/optimium lining most of the time both implanted, but one did not develop very far.

[Sarah770]

I would transfer the 5AB first and separate: research shows that double transfers slightly improve the percentage of pregnancy (it does not double your chances at all) and some early research seems to indicate that one embryo might influence the other. Not worth it at all with two excellent embryos such as yours.

[VeeVee_bb in reply to Sarah770]

Thanks Sarah770. I think only 1 of the 2 is normal (if lucky) hence the dilemma..

[Sarah770 in reply to VeeVee_bb]

Do not make any assumptions. Operate under the premise that both are normal. Recent studies have shown that embryos that came back aneuploid from PGDs and that were transferred anyway resulted in healthy and viable pregnancies. You do not know.

[Loveelou]

I had a double transfer, one untested A grade embryo the other untested C grade from the same collection just before I turned 40. It was my second transfer a FET. Prior to that I had a failed fresh transfer. I am now 31 weeks pregnant with a single baby. My clinic don't use the formal grading just A-C are transferrable. Sometimes I really think it comes down to having a good lab and embryologist but of course the biggest factor is age.

[VeeVee_bb in reply to Loveelou]

Congrats Loveelou!

I know grading can be subjective; so very indecisive here.. good to see the differing views on here.