Multiple Transfers

[JB124]

Hi everyone.. hope everyone’s as well as can be.. I had my 8th planning consultation today discussed my previous failed transfer (biochemical) and discussed my plan to go for another FET.

I’ve so far had 7 transfers (11 embryos all day 5 and 6 - good grades but untested) I know I’m so so fortunate to have embryos but so exhausted after so many failed rounds. (5 no implantation and 2 back to back biochemical).

My consultant suggest to keep trying and not keen on doing any other test due to lack of evidence. He sees no reason to test the genetics of the embryo because we’re getting good grades and not having miscarriages at later stages. I’ve just had the standard test under NHS

Looking for any success stories, has anyone else had multiple transfers with own eggs and then had success.. I’m starting to lose hope now.. .

[Memacha]

I’m sorry you’ve had to go through so much disappointment, it really sucks to have so many good embryos and nothing wrong but it still doesn’t work. I’ve found unexplained infertility incredibly frustrating. There must be a reason but the doctors haven’t figured out what it is yet. Personally I’d want to get more tests done, just because there isn’t sufficient evidence for stuff to be proven doesn’t mean it’s not real or true. I took the microbiome test which is relatively inexpensive which showed I had some inflammation and no good bacteria which could have been affecting implantation. And it’s been a relatively cheap and easy thing to fix. It’s so hard to know which further tests to do, I just picked this as it wasn’t as expensive as some of the others and there’s so much talk about gut health these days and how it impacts other parts of your health. I know it’s so demoralising going through this but I really hope you get some answers and good news soon

[Sja1981 in reply to Memacha]

I want to do a gut cleanse and also test the microbiome. Which test did you do? 🙏

[Memacha in reply to Sja1981]

I did a home test with invivo then took their probiotics. I had a repeat test done with fertilysis a bit later which showed improvement

[Infragilis]

Hi, if you are able to, maybe you could have more tests carried out or maybe a different protocol. On yourself you could have microbiome test, I had a lot of bad bacteria and have been taking probitiocs which fixed the problem. I was given a protocol with steroids although I don't have high natural killer cells. We also had a DQA match test done which showed that my body would reject approx. 50% of our embryos. There is also tests on embryos. Ours were always good quality however we now found out our last miscarriage was down to chromosomal deficiencies. I think there always has to be a reason, however medicine is not yet as advanced yet or they haven't done the right test yet. It took us 5 years for someone to recommend a karyotype of my husbands sperm which resulted to have some problems although his normal karyotype is fine. I would recommend trying to ask for more tests. Wishing you the best of luck.

[Sja1981 in reply to Infragilis]

Which probiotics are you taking? 🙏

[Infragilis in reply to Sja1981]

I take optibac every day extra

[HedgehogMad]

Hi lovely, so sorry to you are going through this. Ive had a similar journey and did a LOT of research into RIF (I am also a doctor by profession which probably didn't help the rabbit holes ha). And spoke to 3 different RIF specialists who all essentially said the same thing which was to ensure you're transferring euploid embryos and no evidence for most other tests. I have concluded that the tests/treatments I'd recommend for someone in my situation would be:PGTA testing (the stats are clear on this that after transferring 3 euploids 95% of women will have a live birth, and 98% after 5 euploids). Transferring untested would mean you'd always be wondering whether it's you or the embryos - the vast majority of cases is the embryo

Karyotype testing for both parents (as sometimes issues won't be picked up on standard PGTA)

3D ultrasound of the womb to check for adenomyosis that might not be seen on standard USS

HSG to exclude issues with the tubes that might be affecting implantation

If you have any unusual pelvic pains then I'd also suggest seeing an endometriosis specialist for an opinion also.

Hope this is helpful and I really wish you success, it's such an awful situation to be in xx

[Doodlebug23]

Not with OE. But took me 7 transfers to get my BFP. My clinic added steroids and clexane but other than that basically said it’s a numbers gave keep going.