Opinions / Evidence on Natural Modified FET

[Sunshine92]

Hi lovely ladies and gents,

I had a second consultation with my clinic consultant today about next steps and i fear im loosing trust. You’d hope with the amount of money you pay care would be more person centred although i feel its not … anyway.

2 recent failed FET on standard HRT protocol. I have 3 frozen embryos left all of good quality. Consultant recommended ERA + EMMA and ALICE which sounded promising but after leaving and doing my own research ghe evidence for this is poor.

I have a little boy from a fresh cycle and so asked about modified natural FET (consultant discounted natural FET as i have difficulty getting a positive LH peak although i have natural cycles) but didn’t discuss modified at all. After your advice i discussed this with her, she said she would be happy to try it but said evidence is about the same as ERA. I’m struggling to find any evidence for natural modified FET.

Has anyone got any experience of evidence they can share?

[Doodlebug23]

My clinic didn’t advocate ERA EMMA ALICE, I would think for the same reasons you’ve found when doing your own research.

My successful transfer was modified natural so I’m a big advocate of it for obvious reasons!

[Sunshine92 in reply to Doodlebug23]

Thank you so much. She said her evidence for ERA is anecdotal and shared with me data gathered from the clinic company across the country where they found it to benefit. Im just so anxious and want to give us the best chance. I feel like ive lost a bit of trust now with the clinic x

[Doodlebug23 in reply to Sunshine92]

I know someone on here did ERA, followed the results and BFP, then went back to normal timings and BFP…. My clinic says it changes with each cycle so isn’t really of use.

Totally understand and know that feeling of being willing to do anything you can to make it work. Unfortunately that sometimes leads you down a path that doesn’t actually give any benefit.

I must admit I had total trust and confidence in my clinic the whole way through, even through the failed transfers.

The natural cycle really makes sense to me as your body is just doing its natural thing. Y to the first time I had scans to monitor ovulation but the second I used POAS ovulation tests. X

[Vix12345]

Ok so I have had 4 frozen transfers (plus one fresh which resulted in a negative test). The first two were medicated, with extra clexane and aspirin and alone was a single embryo transfer and one a double transfer. They both resulted in chemicals which were positive early on but negative by test day (no trigger shot). The third frozen we decided to try a natural frozen transfer, but starting progesterone, clexane and aspirin 5 days before transfer. Again no trigger was used and two embryos were transferred. This did have a positive result, but at the 6 week scan they said there was nothing there. I was then sent to the hospital EPU for miscarriage management and they found a heartbeat and all looked good but a few days behind. Unfortunately this ended in miscarriage at 9 weeks.

The fourth frozen transfer we decided to mimic the previous round as that had worked, and we only had one embryo left. A trigger shot was used this round in addition to the same progesterone, clexane and aspirin meds. Thile result of this round was negative.

We have now used all our embryos but are lucky to have paid for another cycle and will be starting that again in a few months. My clinic are brilliant and will try almost anything I suggest. This time they have suggested PGTA testing which I was reluctant about due to the cost but have decided to go ahead with, so the egg collection round will be a freeze all whilst waiting on the results of that. I have asked for the ERA test whilst waiting on those results so we will be doing another round for that where no embryo is out back. On the round we then actually put an embryo back we will know it's a good quality, tested embryo going back at the time best determined for me. We will be mostly following the same protocol but adding in steroids too.

So whilst I can't say yet if the era and pgta testing make a difference, I do feel quite confident that for us it's the best option for peace of mind that we have done all we can.

Beat of luck whatever you decide. x